Assessment Of Optical Performance And Comparison Of Virtual Clinical Implant For Two Full Vision Range Intraocular Lenses

The Clareon PanOptix (CPO) Pro (Alcon Vision) and Tecnis Odyssey (JnJ Vision) are two Presbyopia Correcting Intraocular Lenses (PC IOLs). Both these IOLs are designed to provide simultaneous distance, intermediate, and near vision for cataract patients. The purpose of this study is to evaluate the optical performance and the subjective responses after monocular virtual implant of each IOL using a vision simulator.

Optical performance study is based on Modulation Transfer Function (MTF) system at Alcon Research, LLC, Fort Worth, Texas, USA. The subjective assessment with virtual implantation was done at JENVIS Research, Jena, Germany.

Optical performance was compared using an IOL Research bench system for the CPO Pro and Odyssey IOLs. A VirtIOL system was used to virtually implant IOLs in 63 phakic, cyclopleged subjects. Pupil size was fixed at 3.5mm for photopic and 4.5mm for mesopic testing. Monocular subjective blurriness ratings were collected at distance, -1.5D and -2.5D of defocus distances when viewing a photopic high contrast 0.2logMAR line. Subjects used an adjustable ring to indicate the perceived size of halo and starburst with each IOL while viewing an LED source in mesopic conditions. Preference for each IOL on intermediate vision quality and halo/starbursts was also collected. 

MTF data from the optical bench revealed a negligible difference in distance image contrast between these two PC IOLs. The CPO Pro, however, achieved 36% higher image contrast in the intermediate-to-near vision range (-1.5D to -2.5D) as compared to the Odyssey IOL.

With virtual implant, subjective blurriness rating differences at distance and near were within 1.5 units.  The blurriness scores at intermediate were larger than 2.5 units for Odyssey compared to PanOptix Pro. 89% of subjects preferred CPO Pro for intermediate vision quality.  The response to a question on the tolerance to halo, 70% of the subject prefer CPO Pro. Likewise, 89% preferred CPO Pro over Odyssey for the tolerance of starburst.

The in vitro optics bench data demonstrated higher image contrast in the intermediate range and less halo for CPO Pro as compared to Odyssey. 89% of subjects reported a preference for PanOptix® Pro over Odyssey® for simulated intermediate vision. 70% and ~90% of subjects preferred PanOptix® Pro over Odyssey® with respect to tolerating halo and starburst, respectively.