Impact Of Presbyond® Laser Blended Vision Surgery For Presbyopia Correction On Five Key Patient Reported Outcomes

PRESBYOND® Laser Blended Vision, a specialized LASIK-based surgical procedure designed to treat presbyopia, has shown promising clinical outcomes and high patient satisfaction. However, the treatment efficacy on quality of life (QoL) outcomes more generally is unclear. We aimed to determine the impact of PRESBYOND® on patients’ vision-related QoL (VRQoL) and patient-reported outcomes specific to refractive interventions using novel, validated, condition-specific computerized adaptive tests (CATs).

In a pre-post study, 29 patients aged 40 years and above with a stable refractive error and developing presbyopia underwent bilateral PRESBYOND® surgery for refractive error correction at the Laser Vision Centre, Singapore National Eye Centre (Jan-Nov 2025). Those with active eye conditions (e.g., cataracts, glaucoma or retinal diseases) or corneal abnormalities (e.g., keratoconus, irregular astigmatism or abnormal corneal topography) were excluded.

Patients were interviewer-administered the Emotional (EM) and Vision Functioning (VF) domains of the Impact of Vision Impairment CAT (IVI-CAT); and the Comfort (CF), Concerns (CN) and Convenience (CV) domains of the Myopia Refractive Intervention CAT (MyoRI-CAT) in-clinic via a web-based application. Assessments were conducted at baseline and 1-month post-surgery. Sociodemographic and clinical information were collected via an in-house questionnaire. Baseline spherical equivalent (SE) was calculated, and participants were categorized into low myopia (better eye SE ≤-3.0 diopters [D]; n=13) or moderate-high myopia (SE: >-3.0D; n=16). Change in the five QoL outcomes was assessed using a paired t-test in the overall and stratified samples.

For the 29 patients (mean±SD age 47.5±3.9; 65.5% female) CF, CV, VF and EM scores increased significantly at 1-month post-treatment (e.g., CF: baseline 64.7±29.3 to follow-up 89.9±15.9; 38.9% increase; p<0.001). In stratified analyses, significant improvements in CV scores were only observed in the low myopia group and, while CF scores were significantly higher post-treatment in both groups, the magnitude of the gains was larger in those with low myopia (17.4 vs. 34.9, respectively). In contrast, significant increases for EM and VF were only observed in the moderate-high myopia group. However, in a direct comparison, these between-group differences were not statistically significant.

Overall, our findings suggest that PRESBYOND® surgery for presbyopia correction has a substantial positive effect on several aspects of patients’ VRQoL, including vision functioning, emotional well-being, comfort and convenience. The magnitude of  QoL outcomes may depend on the degree of refractive error at baseline, with substantially lower gains observed in those with more myopic refractive error; however, differences were not statistically significant and larger sample sizes are required to confirm this finding.