Iol Power-Stratified Short-Term Efficacy And Optical Performance Of Zeiss Ct Lucia 621P Iol In Cataract Patients

To evaluate the short-term efficacy and optical performance of the ZEISS CT LUCIA 621P IOL in cataract patients, using a diopter-stratified approach to assess whether its non-constant aspheric design mitigates power-dependent aberrations across a wide IOL power spectrum

Single center, retrospective , comparative study

This study includes 304 eyes from cataract patients with CT LUCIA 621P implantation. IOL power was calculated using the BU II formula. Eyes were grouped by IOL power: Group 1 (<20.0 D, n=49), Group 2 (20.0–21.5 D, n=137), Group 3 (22.0–23.5 D, n=60), and Group 4 (≥24.0 D, n=58). Outcomes included UDVA/CDVA, UIVA and UNVA , cumulative Snellen VA percentages, defocus curves (mono/binocular, photopic/mesopic), internal HOA (spherical and coma), contrast sensitivity at 1 month, and refractive errors, assessed at 1 ,3 months. Multivariable regression adjusted for age, sex, and pupil size. Statistical analyses employed ANOVA for initial comparisons and General Linear Model for inter-group differences and temporal changes (p<0.05).

: All groups achieved excellent mean UDVA (0.10–0.21 logMAR, p=0.162),with balanced UIVA ( 0.38–0.40 logMAR, p=0.542) and UNVA ( 0.56–0.58 logMAR, p=0.577).Cumulative Snellen VA showed ≥95% of eyes reaching 20/32 or better, with Group 2 and 3 demonstrating superior stability. Defocus curves were comparable across groups,maintaining tolerance under photopic and mesopic conditions. Internal HOAs stayed low and stable (SA RMS ~0 across groups, change <0.02 RMS; coma RMS p=0.465),confirming optical consistency at 3 months.CS at 1 Mo was robust across groups (1.5 cpd: 1.25–1.37 logCS; 18 cpd: 0.40–0.54 logCS, p>0.05),with intermediate powers (Groups 2/3) trending higher. Refractive outcomes stabilized by 3 months (SE: -0.48 to -0.83 D, p=0.452).

The non-constant asphericity of the CT LUCIA 621P preserves visual quality across diopter ranges, with balanced efficacy and stability by 3 months, particularly in intermediate powers. This diopter-stratified analysis provides novel subgroup evidence for its utility in cataract patients, informing personalized IOL selection.