Biologically Assisted Refractive Surgery: The Role Of Dehydrated Amniotic Membrane And Locally Prepared Platelet Rich Plasma Trans-Prk/ Prk And Icl.

The Role of Dehydrated Amniotic Membrane and Locally Prepared Platelet-Rich Plasma in Trans-PRK/PRK and ICL.

To evaluate the impact of biologically assisted strategies, including dehydrated amniotic membrane (Amniotek®) and locally prepared platelet-rich plasma (PRP), on visual recovery, ocular surface stability, and patient comfort following Trans-PRK/PRK and Implantable Collamer Lens (ICL) surgery.

This prospective comparative study included 60 patients, comprising 35 patients undergoing Trans-PRK/PRK and 25 patients undergoing ICL implantation. In the biologically assisted group, Trans-PRK/PRK patients received postoperative application of a dehydrated amniotic membrane combined with locally prepared PRP, while ICL patients underwent preoperative ocular surface optimization and short-term postoperative treatment with locally prepared PRP. Outcomes were compared with a standard postoperative management group. Primary outcome measures included time to epithelial healing, uncorrected distance visual acuity (UDVA), postoperative pain, tear break-up time (TBUT), Ocular Surface Disease Index (OSDI), and patient satisfaction.

In the Trans-PRK/PRK cohort, biologically assisted management resulted in faster epithelial healing, reduced postoperative pain, and earlier visual recovery compared with standard care. A lower incidence of corneal haze and improved ocular surface stability were observed during follow-up.

In the ICL cohort, patients receiving PRP-based ocular surface optimization reported improved postoperative comfort, better subjective visual quality, and fewer dry eye symptoms, despite comparable refractive accuracy between groups.

The integration of dehydrated amniotic membrane  and locally prepared PRP into refractive surgery protocols enhances early visual recovery, ocular surface stability, and patient comfort after Trans-PRK/PRK and ICL procedures. Biologically assisted refractive surgery represents a practical and reproducible strategy to optimize functional outcomes beyond refractive precision alone.