Clinical Outcomes Of Conventional Vs. Transepithelial Photorefractive Keratectomy: A Prospective Randomised Double-Blinded Contralateral Eye Study

Published 2026 - 44th Congress of the ESCRS

Reference: POREF211 | Type: Free paper | DOI: 10.82333/43ny-n340

Authors: Dr Adeya Mohammed Alharami* ¹ , Dr M.Basil Marchi ¹ , Dr Omar Al Qahtani ¹ , Mr Joenie Anilao ¹ , Mr Shanudheen chekkumpadykunnu ¹ , Dr Hashem Abu Serhan ¹

¹Ophthalmology Department ,Hamad Medical Corporation,Doha,Qatar

Purpose

To compare the clinical outcomes of conventional photorefractive keratectomy (PRK) and single-step transepithelial PRK (TransPRK) for the correction of myopic refractive errors in a contralateral eye study model.

Setting

This prospective, paired-eye, comparative study was conducted at Hamad Medical Corporation (HMC), Ophthalmology Department. A total of 24 consecutive patients (48 eyes) with myopia or myopic astigmatism were enrolled. The study adhered to the tenets of the Declaration of Helsinki, and all participants provided informed consent after a thorough explanation of the procedures and potential risks. Each patient underwent conventional PRK in the right eye (OD) and TransPRK in the left eye (OS).

Methods

This prospective, paired-eye comparative study included 48 eyes of 24 patients. Each patient underwent conventional PRK in the right eye and TransPRK in the left eye. Both patient and outcome assessors were blinded to treatment allocation. Preoperative and postoperative parameters including uncorrected distance visual acuity (UDVA), spherical equivalent (SE), postoperative pain, epithelial healing time, and complications were evaluated. Paired statistical analyses were used to compare outcomes between the two procedures.

Results

There were no significant differences in baseline characteristics between the groups. Postoperatively, there were no statistically significant differences in UDVA (p=0.084) or final SE (p=0.512). Epithelial healing was faster in the TransPRK group but failed to show statistical significance (p=0.371). However, postoperative pain was significantly higher in the TransPRK group, with a median pain score of 8 (IQR 8–10) compared to 6 (IQR 6–8) in the PRK group (p=0.014). Clinically significant postoperative haze was observed in 3 (12.5%) of patients, with an identical pattern in both eyes of every affected patient.

Conclusions

Both conventional PRK and TransPRK are safe and effective procedures for myopic correction, providing comparable visual and refractive outcomes. In this cohort, TransPRK was associated with significantly greater early postoperative pain, a finding that contrasts with much of the existing literature and warrants further investigation. The contralateral study design highlights the consistency of other outcomes while isolating this key difference between the two procedures.