ESCRS - POREF012 - Early Clinical Experience With The Xenia High Refractive Index Corneal Inlay For Presbyopia

Early Clinical Experience With The Xenia High Refractive Index Corneal Inlay For Presbyopia

Published 2026 - 44th Congress of the ESCRS

Reference: POREF012 | Type: Case Report | DOI: 10.82333/bqmg-9x03

Authors: Mr Marwan Ghabra* 1 , Dr Hakam Ghabra 2 , Dr Hala Almohi Alsaid Mushaweh 3

1Ophthalmology,Whipps Cross University Hospital,Queen Mary University of London  ,London,United Kingdom, 2Medical Department,Arab International University,Damascus,Syrian Arab Republic, 3Ophthalmology,University of aleppo,Aleppo,Syrian Arab Republic

Purpose

To present early clinical outcomes following implantation of the XENIA high refractive index intrastromal corneal inlay for the treatment of presbyopia.

Setting

Ministry of Health Hospital, Damascus, and a private refractive surgery centre.

 

Report of case

Two presbyopic patients underwent implantation of the XENIA corneal inlay ( Implantation in non-dominant eye, Femto-pocket; depth: 350µm,

Lenticule Specifications diameter 1.8mm, thickness of Lenticule 30 to 35µm.). The device was positioned intrastromally under femtosecond laser-created lamellar access. Pre- and postoperative assessment included uncorrected distance visual acuity (UDVA), uncorrected near visual acuity (UNVA), distance-corrected near visual acuity (DCNVA), corneal topography, epithelial thickness mapping, anterior segment OCT imaging, wavefront aberrometry, and patient-reported visual quality and satisfaction.

Early postoperative findings demonstrate improvement in uncorrected near visual acuity with slight reduction of distance vision. Anterior segment OCT confirms stable intrastromal positioning of the implant. Epithelial mapping shows no central remodeling. No visually significant induction of higher-order aberrations was observed in early follow-up. Both patients reported functional improvement in intermediate and near visual tasks with acceptable quality of vision.

Extended follow-up data, including defocus curve analysis and longer-term epithelial behaviour, will be presented at ESCRS London 2026.

Conclusion/Take home message

The XENIA high refractive index corneal inlay appears to represent a promising additive optical approach for presbyopia correction. Early outcomes suggest predictable refractive effect with structural stability. Larger prospective studies are required to confirm long-term safety and efficacy.