ESCRS - POGAU066 - Real-World Predictors Of 12-Month Success Of A Supraciliary Drainage Device (Star-Life)

Real-World Predictors Of 12-Month Success Of A Supraciliary Drainage Device (Star-Life)

Published 2026 - 44th Congress of the ESCRS

Reference: POGAU066 | Type: Free paper | DOI: 10.82333/fa10-de33

Authors: Prof. Dr Kaweh Mansouri* 1 , Ewald Lindner 2 , Karsten Klabe 3 , Burkhard Dick 4 , Swantje Grisanti 5 , Sheng Lim 6

1Ophthalmology,Swiss Visio Network,Lausanne,Switzerland, 2Meduni Graz,Graz,Austria, 33. Breyer, Kaymak & Klabe Augenchirurgie,Duesseldorf,Germany, 44. University Eye Hospital, Knappschaftskrankenhaus,Bochum,Germany, 55. Universitätsklinikum Schleswig-Holstein,Luebeck,Germany, 6St Thomas Hospital,London,United Kingdom

Purpose

Baseline predictors of 12-month success in glaucoma patients post-implantation of a minimally-invasive drainage device (MINIject®; iSTAR Medical, Belgium) implanted into the supraciliary space was studied in a real-world setting. Patients were treated in either a standalone procedure (phakic or pseudophakic) or combined with cataract surgery, and followed according to the surgeon’s standard of care.

Setting

STAR-LIFE is a real-world registry with follow-up until two years in up to 320 adult patients. From 13 sites in Switzerland, UK, Germany, and Austria, a preliminary, interim analysis of the first 218 patients with 12-month follow-up was performed to determine whether any baseline factors influenced success. Patients were predominantly diagnosed with POAG (73.4%) or pseudoexfoliation glaucoma (17.0%). They were majority Caucasian (85.8%) or of African descent (7.8%).

Methods

Success was defined as IOP≤21mmHg with no secondary surgery for IOP, and no medication increase, with either IOP-lowering ≥20% or a medication reduction compared with baseline. Factors associated with success with a p-value <0.20 in the univariate analysis were introduced into the multivariate analysis. Collinearity was evaluated, with a correlation coefficient >0.50 considered strong. Separate multivariate models evaluated strongly collinear variables.

Results

The average visual field mean deviation (VF MD) was -9.5±7.6 dB (moderate severity) and the investigator assessed patients as having mostly moderate (40.8%) or severe (32.1%) glaucoma. Standalone MINIject implantation was performed in 71.6% of cases. Secondary IOP-lowering surgery was performed in 17.0% patients before 12-months, and success was achieved by 57.3% patients. Factors correlated with success were combined surgery (standalone OR: 0.32 [0.15, 0.69]; p=0.004) and lower IOP at 3 months (high IOP OR: 0.88 [0.83, 0.94]; p<0.001). Age, gender, lens status, glaucoma severity, prior glaucoma surgery, prior SLT/ALT/ECP, CAI use at baseline, and starting IOP or medications were not significantly correlated with success.

Conclusions

In this predominantly Caucasian, POAG population in various European centres in the STAR-LIFE study, combined surgery and IOP at 3 months increased the likelihood of success after MINIject implantation.