Histopathological Changes Of The Conjunctiva Following Cataract Surgery
Published 2026 - 44th Congress of the ESCRS
Reference: POCOR557 | Type: Poster | DOI: 10.82333/say3-kg09
Authors: Dr Evangelia Stangogianni* 1 , Dr Crisanti Stangogiannis 1
1ANTERIOR SEGMENT,LASERLENS,IOANNINA,Greece
Purpose
To determine the effects of topical dexamethasone with concomitant application of topical serum autologous 10% on the conjunctival goblet cell density in eyes after cataract surgery.
Setting
LASERLENS IMHN IOANNINA GREECE
Methods
Design: Randomized clinical trial.
Participants: One hundred eyes from fifty patients with dry eyes who were scheduled for cataract surgery.LA
Patients were randomly divided into two groups according to the postoperative topical drugs to be given; Group A (Right eye), dexamethasone alone; Group B (Left eye), dexamethasone and serum autologous 10%. Impression cytology was performed 1 month before surgery and 3 months after the surgery, and the mean density of goblet cells was determined.
Results
The density of goblet cells before the surgery in Group A, was 247.0 ± 178.7 cells/mm2 (mean ± SD), and it decreased significantly to 76.5 ± 66.7 cells/mm2 (mean ± SD) at 1 month after the surgery (P = .002). In Group B, the goblet cell density was not statistically different between before (228.5 ± 106.6 cells/mm2) (mean ± SD) and at 3 month after the surgery (201.3 ± 174.4 cells/mm2,(mean ± SD), P = 0.55).
Conclusions
The conjunctival goblet cell density was significantly reduced because of the inflammatory response to the corneal incisions that interrupt the nerve communication. Also, the concomitant use of topical serum autologous 10% with dexamethasone drugs were beneficial, especially in cases with postoperative dry eyes.