Efficacy Of Quantum Molecular Resonance Electrotherapy In Neuropathic Corneal Pain And Corneal Nerve Regeneration

To investigate the efficacy of Quantum Molecular Resonance (QMR) electrotherapy for pain relief in neuropathic corneal pain (NCP) patients, to assess its potential to stimulate corneal nerve regeneration, and to explore the underlying molecular mechanisms involved.

Singapore National Eye Centre

Twenty NCP patients underwent 8 weekly QMR electrotherapy. At baseline and each treatment visit, the Visual Analogue Scale (VAS), Ocular Pain Assessment Survey (OPAS), and ocular surface assessments were conducted. In-vivo confocal microscopy (IVCM) was performed to evaluate 7 corneal nerve parameters. Patient acceptability and satisfaction were also assessed. Tear proteomic profiles were evaluated using enzyme-linked immunosorbent assay and quantitative tear proteomic analysis.   

At 8 weeks, the VAS pain scores significantly reduced compared to baseline (2.6 vs 5.0;  P=0.021). There was significant improvement in the OPAS scores, in the ocular pain relief, interference with general activity, mood, and interaction with people. Corneal sensitivity significantly improved. Corneal nerve fiber density, length, and total branch density significantly increased. The majority of patients rated QMR treatment as pleasant (80%), effective (53.3%), durable (66.7%), comfortable (73.3%), and satisfied (66.7%). Tear substance P levels significantly decreased. Proteomic analysis showed neurotoxicity and neutrophil degeneration were significantly downregulated, while axonal signaling was significantly upregulated after treatment.

QMR electrotherapy is effective in alleviating neuropathic pain and improving corneal sensitivity in NCP patients. It also potentially promoted corneal nerve regeneration.