Corneal Biomechanics Screening Assessment In Keratoconus Detection Using Corvis St In Pediatric And Young Adult Population: A Prospective Cohort Study In Uzbekistan

Published 2026 - 44th Congress of the ESCRS

Reference: POCOR355 | Type: Free paper | DOI: 10.82333/cqnz-z555

Authors: Mrs Nikki Leilah Hafezi* ¹ , Dr Shakhnoza Azizova ² , Dr Abdulrashid Rustamjonov ³ , Mr Abdulaziz Ergashaliev ³ , Mr Kudratillo To'xtasinov ³ , Mr Jaloliddin Khurramov ² , Mr Jasurbek Sodikov ² , Prof. Dr Kamoliddin Salakhidinov ⁴ , Prof. Dr Farhad Hafezi ⁵

¹Ophthalmology,ELZA Institute,Zurich,Switzerland;Light for Sight Foundation,Zurich,Switzerland;GroupAdvance Consulting,Zug,Switzerland, ²GroupAdvance Medical FE LLC,Tashkent,Uzbekistan, ³Andijan State Medical University,Andijan City,Uzbekistan, ⁴Department of Faculty and Hospital Surgery,Andijan State Medical University,Andijan City,Uzbekistan, ⁵Ophthalmology,ELZA Institute,Zurich,Switzerland;Center for Applied Biotechnology and Molecular Medicine,University of Zurich,Zurich,Switzerland;Faculty of Medicine,University of Geneva,Geneva,Switzerland;Keck School of Medicine,University of Southern California,Los Angeles,United States;Ophthalmology,NYU Grossman School of Medicine,New York,United States

Purpose

To evaluate the diagnostic performance of corneal biomechanical parameters measured with Corvis ST (Oculus Optikgeräte, Wetzlar, Germany) for the detection of keratoconus in pediatric and young adult populations. Early identification of ectatic disease remains challenging, particularly in regions where advanced corneal tomography is not widely accessible. This study assesses whether biomechanical evaluation may serve as a feasible pre-screening strategy for early keratoconus detection in resource-limited settings where access to advanced corneal tomography may be limited.

Setting

Andijan State Medical University, Andijan, Uzbekistan. Prospective, single-center observational cohort study.

Methods

A total of 580 children and adolescents (<18 years) and 579 young adult medical students underwent corneal biomechanical assessment using the Corvis ST and corneal tomography using Pentacam HR (Oculus Optikgeräte, Wetzlar, Germany). Participants with prior corneal surgery were excluded. Biomechanical parameters were analyzed in relation to tomographic findings to assess their diagnostic utility for detecting keratoconus.

Results

Data collection has been completed, and statistical analysis is currently ongoing. Final numerical results will be presented.

Conclusions

This study should clarify the role of corneal biomechanical assessment in the detection of keratoconus and explore its potential as a prescreening strategy, particularly in resource-limited settings without access to corneal topography instrumentation.