The State Of The Immune System In Patients With Keratouveitis Associated With Nonspecific Ulcerative Colitis
Published 2026 - 44th Congress of the ESCRS
Reference: POCOR222 | Type: Poster | DOI: 10.82333/cewr-p183
Authors: Prof. Nataliya Konovalova* 1 , Dr Olga Guzun 2 , Dr Olexii Kovtun 1 , Prof. Ludmila Velichko 2
1Department of General, Pediatric, and Military Surgery with a Course in Urology and Ophthalmology,Odessa National Medical University,Odesa,Ukraine, 2SІ "The Filatov Institute of Eye Diseases and Tissue Therapy of the National Academy of Medical Sciences of Ukraine”,Odesa,Ukraine
Purpose
To study the level of expression of apoptosis markers (CD 95), intercellular adhesion ICAM-1 (CD54), as well as CD3, CD4, CD8, CD25, CD38 in patients with uveitis and macular edema associated with nonspecific ulcerative colitis as a complication after cataract extraction.
Setting
Setting: The study was prospective and conducted in two highly specialized ophthalmological centers specializing in the study of the immune status of patients with uveitis at the University Clinic of the Odessa National Medical University and the State Institution V.P. Filatov Institute of Eye Diseases and Tissue Therapy of the National Academy of Medical Sciences of Ukraine.
Methods
We observed 49 patients with uveitis and macular edema associated with nonspecific ulcerative colitis as a complication after cataract extraction.To study the level of expression of apoptosis markers (CD 95), intercellular adhesion ICAM-1 (CD54), as well as CD3, CD4, CD8, CD25, CD38
Results
A decrease in CD3 levels was observed in 74.1% of patients; a decrease in CD4 levels in 76.6% of patients; a decrease in CD8 levels in 77.1%; and a decrease in CD25 levels in 73.4% of patients. An increase in CD38 levels was observed in 72.3% of patients; an increase in CD54 levels in 75.7%; and an increase in CD95 levels in 76.4% of patients
Conclusions
Patients have pathologically low levels of CD4, CD8, and CD25, and over expression of CD38, ICAM-1, and CD95, which causes immune cell apoptosis, lymphopenia, and an exhausted T-cell phenotype with up regulated inhibitory receptors.