ESCRS - POCAT573 - Glistenings Formation In The Clareon® Sy60wf And Tecnis® Pcb00 Intraocular Lens Platforms: A Long-Term In Vitro Natural Aging Experiment

Glistenings Formation In The Clareon® Sy60wf And Tecnis® Pcb00 Intraocular Lens Platforms: A Long-Term In Vitro Natural Aging Experiment

Published 2026 - 44th Congress of the ESCRS

Reference: POCAT573 | Type: Free paper | DOI: 10.82333/6hqs-kz50

Authors: Mr Nick Stanojcic* 1 , A/Prof. Christopher Hull 2 , Dr Eva Philippaki 3 , A/Prof. David O'Brart 4

1Ophthalmology,West Suffolk NHS Foundation Trust,Bury St Edmunds,United Kingdom, 2Optometry and Visual Science,City St George's University of London,London,United Kingdom, 3Physics,King's College London,London,United Kingdom, 4Ophthalmology,Guy's and St Thomas' NHS Foundation Trust,London,United Kingdom

Purpose

To study the development of glistenings in two hydrophobic acrylic intraocular lenses (IOLs) through natural aging

Setting

Centre for Applied Vision Research, City St George’s, University of London

Methods

Ten Clareon® SY60WF (Alcon Inc., USA) and seven Tecnis® PCB00 (Johnson & Johnson Inc., USA) IOLs were evaluated.  Glistenings formation was observed following a novel natural aging experiment after 33.7 ± 0.1 months (mean ± standard error) following incubation of IOLs at a constant temperature of 37oC. Rapid thermal aging was applied at the end of the ‘natural’ aging experiment. Size and density of glistenings were objectively evaluated following a standardised imaging protocol and manual highlighting using public domain open-source software

Results

The median [range] glistening counts were 88 [17 to 1432] for the Clareon® and 23 [5 to 391] for the PCB00® IOLs (P = 0.22) after natural aging.  The median equivalent glistenings diameters for Clareon® and PCB00® IOLs were 20.3 [10.1, 50.5] and 12.2 [8.6, 23.4] microns respectively (P < 0.001) after natural aging. Following thermal aging, the median change in number of glistenings was -3 for the Clareon® and +5 for the PCB00® IOLs (P=0.44 and P=1, respectively)

Conclusions

Resistance to glistenings formation of Clareon® and PCB00® IOLs has been confirmed in a natural aging experiment.  The higher density and the larger diameter of glistenings for the Clareon® IOLs may reflect inter-IOL variation, which was large.  Stability to thermal insult following natural aging may suggest that glistenings development is non-linear and equilibrium can be reached