In Vitro Optical Performance For The Next Generation Trifocal Intraocular Lens: Comparative Bench Analysis Of Clareon Panoptix Pro And Clareon Panoptix

To evaluate the in vitro optical performance of a modified trifocal intraocular lens (IOL), Clareon PanOptix Pro, and compare it with the established Clareon PanOptix platform. The analysis focused on light utilization, light distribution across focal points, and image quality parameters relevant to functional vision, particularly in the distance-to-intermediate defocus range.

Optical bench testing and model eye simulation conducted at Alcon Research, LLC, Fort Worth, Texas, USA.

Total light utilization was quantified using two-dimensional point spread function (PSF) analysis. Modulation transfer function (MTF) measurements were obtained under white-light conditions at distance, intermediate, near, and -1.0 D defocus. The area under the MTF curve (0-70 lp/mm) was calculated. Predicted through-focus binocular visual acuity (VA) was derived from MTF-based modeling to estimate functional optical performance across the defocus range.

Total light utilization increased from 88% with Clareon PanOptix to 94% with Clareon PanOptix Pro. PSF analysis demonstrated redistribution of light energy toward distance and intermediate focal points. White-light MTF showed a 16% higher average value (0-70 lp/mm) at -1.0 D defocus for PanOptix Pro. Predicted through-focus VA suggested a continuous range of vision with maintained performance at distance, intermediate, and near focal points.

Bench testing indicates that the modified trifocal design improves light utilization and enhances optical quality in the distance-to-intermediate range while preserving performance at established focal points. These findings suggest potential functional benefits for far-intermediate tasks; however, confirmation in prospective clinical studies is required.