ESCRS - POCAT423 - Bvi Isopure Serenity Irof: Real-World Clinical Outcomes Of A Novel Isofocal Premium Monofocal Iol

Bvi Isopure Serenity Irof: Real-World Clinical Outcomes Of A Novel Isofocal Premium Monofocal Iol

Published 2026 - 44th Congress of the ESCRS

Reference: POCAT423 | Type: Free paper | DOI: 10.82333/mra1-e954

Authors: Mr Laurence Cox* 1 , Mr Rajesh Deshmukh 2 , Ms Laura De Benito Llopis 1 , Mr Ali Mearza 1 , Mr Allon Barsam 1 , Mr Romesh Angunawela 1

1OCL Vision,London,United Kingdom, 2Moorfields Eye Hospital,London,United Kingdom

Purpose

To evaluate visual outcomes, refractive accuracy and safety of the BVI Isopure Serenity IROF (Increased Range of Focus) monofocal intraocular lens in a real-world clinical series.

Setting

This retrospective multicentre study was conducted at OCL vision in London, United Kingdom.

Methods

Retrospective multi-surgeon analysis of 106 eyes (73 patients) undergoing phacoemulsification or refractive lens exchange with implantation of the Serenity IROF. Monocular and binocular uncorrected distance and near visual acuity and deviation from planned post-operative refraction (PPOR) were assessed.

Results

Mean age was 70.8 years (range 41–91). Monocular UDVA of ≤0.10 logMAR (6/7.5) was achieved in 72%, improving to 95% binocularly (+23 percentage points). Mean binocular UDVA was 0.001 logMAR (6/6). Monocular UNVA of N5 or better was achieved in 28%, rising to 53% binocularly (+23 percentage points). In 73 eyes with complete refractive data, mean deviation from PPOR was −0.05D (SD 0.47D); 83.6% within ±0.50D and 95.9% within ±1.00D of target. More myopic SE was associated with worse distance VA (r = −0.50, p < 0.001) and better near VA (r = 0.41, p < 0.001), consistent with the vergence advantage of residual myopia supplementing the IROF optical mechanism.

Conclusions

The Serenity IROF monofocal delivers excellent distance outcomes with accurate refractive targeting and clinically meaningful near function. Binocular summation confers consistent gains of approximately 23 percentage points at both distance and near thresholds, underscoring the importance of bilateral implantation for optimal outcomes.