Updated Results Of A Prospective Randomized Control Trial To Measure Posterior Capsular Opacification And Visual Outcomes Following Insertion Of Two Monofocal, Aspheric, Acrylic Intraocular Lenses: Hydrophobic Rayone 800C Vs Hydrophilic Rayone 600C.

To compare posterior capsular opacification (PCO), Nd: YAG laser capsulotomy rates, visual outcomes, IOL glistenings and patient satisfaction of patients following insertion of either the hydrophilic RayOne 600C monofocal intraocular lens (IOL) or the hydrophobic RayOne 800C monofocal IOL. Both IOLs are manufactured by the same manufacturer (Rayner Ltd, Worthing, UK) and are structurally similar, with square edges and comparable optic and haptic designs.

University Hospital, London, United Kingdom.

Patients with visually symptomatic cataract were randomised to receive one of the two IOLs during phacoemulsification cataract surgery (CS). Thirty-nine eyes of 39 patients received the RayOne 600C IOL (HPL group) and 46 eyes of 46 patients received the RayOne 800C IOL (HPB group). Patients were seen at baseline and at 1 month (1M), 6M, 12M, and 24M following CS. Primary outcome measures included the development of visually significant PCO requiring Nd: YAG laser capsulotomy and the mean percentage area of PCO within the central 4 millimeters of the IOL as measured from digital photography. Secondary outcome measures include presence of intraocular lens glistenings, visual outcomes, and patient reported outcome measures (CATPROM-5).

Seventy-two patients attended 24M follow-up (37 in HPL group, 35 in HPB group). At 24M, there were statistically significant improvements in UDVA, BDVA and CATPROM-5 scores compared to baseline in the HPL group (all p<0.0001), and in the HPB group (all p<0.0001). At 24 months, 2 patients in the HPL group and 6 patients in the HPB group required Nd: YAG laser capsulotomy for visually significant PCO (p=0.14). Initial analysis of glistenings at 1M and 6M demonstrates increased prevalence in the HPB group (50%, 76.5%), compared to the HPL group (7.14%, 30.77%) (p=0.02) There were no significant differences in visual outcomes, CATPROM-5 scores, or adverse events between the two groups.

Our results indicate there are no statistically significant differences in post-operative visual outcomes and visually significant PCO between the groups. Initial analysis of IOL glistenings suggests an increased prevalence in the HPL group. We will present further 12-month & 24-month IOL glistenings data analysed by three independent assessors.