Metabolic Changes In Aqueous Humor And Prognostic Implications In Diabetic Retinopathy Patients Undergoing Cataract Surgery With Intravitreal Anti-Vegf Therapy
Published 2026 - 44th Congress of the ESCRS
Reference: POCAT211 | Type: Free paper | DOI: 10.82333/5zrk-nk80
Authors: Dr Yumeng Shi* 1 , Dr Yi Lu 1 , Dr Jin Yang 1
1Eye & ENT Hospital of Fudan University,Shanghai,China
Purpose
To explore changes in aqueous humor (AH) metabolites and their prognostic implications in NPDR patients undergoing cataract surgery (CS) with simultaneous intravitreal anti-VEGF injection.
Setting
A single-center, randomized, double-blind clinical trial conducted at the Department of Ophthalmology, Eye & ENT Hospital of Fudan University, Shanghai, China.
Methods
A RCT with 48 eyes divided into experimental (CS with intravitreal Conbercept) and control (CS alone) groups. AH samples were collected intraoperatively and one week postoperatively. Ophthalmic examinations were performed at various intervals postoperatively.
Results
No significant pre- and post-operative AH metabolite changes were observed in the control group. However, significant changes were seen in the experimental group, notably GABA, acetylcarnitine, and oxoglutaric acid. Pathway analysis revealed associations with the Malate-Aspartate Shuttle, Glucose-Alanine Cycle, and Alanine Metabolism. Metabolites like 4-Hydroxybenzoic acid, Aminocaproic acid, and xylose demonstrated high predictive capability for prognosis.
Conclusions
AH metabolite levels remain relatively stable post-CS, but intraoperative anti-VEGF alters its profile. Personalized preventive measures for potential PCME in DR patients are warranted.