Mitomycin Intravascular Chemoembolization For Corneal Neovascularization: A Prospective Imaging-Based Evaluation
Published 2026 - 44th Congress of the ESCRS
Reference: FP08.15 | Type: Free paper | DOI: 10.82333/ncb2-hm41
Authors: Dr Lekha Chandel* 1 , A/Prof. Chintan Malhotra 1 , A/Prof. Amit Gupta 1 , Dr Parul Chawla Gupta 1 , Dr Anchal Thakur 1 , Dr Sonam Yangzes 1 , Dr Jitender Jinagal 1
1OPHTHALMOLOGY,PGIMER,CHANDIGARH,India
Purpose
To evaluate the anatomical and functional outcomes of mitomycin intravascular chemoembolization (MICE) for corneal neovascularization using objective angiographic and structural imaging parameters.
Setting
Single-centre, tertiary referral cornea service at an academic ophthalmology institute in India
Methods
This prospective interventional study included 10 eyes with clinically significant corneal neovascularisation treated with MICE. Patients were evaluated at baseline, 1 month, and 4 months post-procedure. Outcome measures included anterior segment fluorescein angiography (AS-FA)–derived percentage area of actively perfused corneal neovascularisation, zone-wise corneal densitometry, composite severity score, and best-corrected visual acuity (BCVA). Statistical analysis was performed using appropriate parametric or non-parametric tests, with p < 0.05 considered statistically significant.
Results
MICE resulted in a significant reduction in the AS-FA–derived percentage area of actively perfused corneal neovascularisation from baseline to 4 months (p = 0.001). Corneal densitometry demonstrated significant stromal clearing in the central (0–2 mm, p = 0.0039), paracentral (2–6 mm, p = 0.0020), and mid-peripheral (6–10 mm, p = 0.0195) zones, as well as in total corneal densitometry (p = 0.0077). Composite severity scores showed significant improvement over follow-up (p < 0.05). BCVA improved numerically, although the changes did not consistently reach statistical significance.
Conclusions
MICE resulted in significant angiographic regression of actively perfused corneal neovascularisation with corresponding stromal optical improvement, particularly within visually critical corneal zones. Objective imaging-based assessment supports the use of MICE as a targeted intervention for corneal neovascularisation.