ESCRS - FP04.11 - Real-World Outcomes From The Itrack Global Data Registry Of Ab-Interno Canaloplasty Combined With Cataract Surgery

Real-World Outcomes From The Itrack Global Data Registry Of Ab-Interno Canaloplasty Combined With Cataract Surgery

Published 2026 - 44th Congress of the ESCRS

Reference: FP04.11 | Type: Free paper | DOI: 10.82333/8e3n-vs98

Authors: Dr Karl Mercieca* 1 , Dr Leonie Bourauel 1 , Prof. Keith Barton 2 , Dr Nathan Kerr 3 , Dr David Lubeck 4

1University of Bonn Eye Clinic ,Bonn,Germany, 2Moorfields Eye Hospital,London,United Kingdom, 3Dr Nathan Kerr Eye Surgery Associates,Melbourne,Australia, 4Private Practice,Mundingburra,Australia

Purpose

To evaluate real-world outcomes of ab-interno canaloplasty combined with phacoemulsification in open-angle glaucoma

Setting

prospective, multicenter, real-world study conducted in the USA, Canada, Europe, Asia, and Australia

Methods

The iTrack Global Data Registry (iTGDR) is a prospective, multicenter, real-world study conducted in the USA, Canada, Europe, Asia, and Australia. This analysis included eyes with primary or secondary open-angle glaucoma that underwent ab-interno canaloplasty using the iTrack or iTrack Advance in combination with phacoemulsification and had at least 12 months of follow-up. Outcomes were assessed at baseline and at the last available follow-up. Success was defined using American Academy of Ophthalmology criteria.

Results

This study included 334 eyes of 250 patients up to November  2025. Mean baseline IOP and medication use were 17.0±5.1 mmHg and 2.05±1.1, respectively, and were significantly reduced to 14.1±3.8 mmHg and 1.2±1.4 medications (p<0.001) at the last available follow up (mean: 20.2±7.8 months). Medication-free eyes increased from 6.6% (n=22) at baseline to 42.5% (n=142) postoperatively. Success was achieved in 62.0% of eyes (n=207) at postop. Intraoperative complications occurred in 0.3% of cases (n=1), postoperative complications in 2.7% of cases (n=9) and 4.2% of eyes (n=14) required additional glaucoma surgery

Conclusions

Canaloplasty performed via an ab-interno approach reduced IOP and medications in patients with primary and secondary open-angle glaucoma. The iTGDR provides valuable real-world evidence on the clinical effectiveness of canaloplasty, supporting evidence-based decision-making in glaucoma treatment.