Exploratory Evaluation Of Vep Characteristics In Relation To Postoperative Visual Function And Neuroadaptation Following Iol Implantation

Postoperative visual performance after multifocal intraocular lens (MIOL) implantation varies among patients, and neuroadaptation has been suggested as a contributing factor. We previously examined the relationship between postoperative visual function, neuroadaptation, and cognitive processing speed measured by MMSE completion time. As an extension of this work, we explored visual evoked potential (VEP) latency and waveform characteristics in relation to postoperative visual function after MIOL implantation.

Nishi Eye Hospital, Osaka, Japan

Between June and November 2025, pattern-reversal VEP was recorded in eight postoperative cataract patients (six multifocal and two monofocal IOL eyes; age range 63–78 years). P100 latency, amplitude, interocular differences, and waveform consistency were evaluated. Visual acuity, subjective visual quality, and MMSE completion time were descriptively assessed for each case.

VEP latency ranged from 105 to 145 ms. Longer latencies tended to occur in older patients and those with reduced visual function. MIOL eyes showed slightly prolonged latency compared with monofocal eyes, but distributions overlapped without a consistent MIOL-specific delay. Cases with excellent visual function showed near-normal latency (110–120 ms), stable waveforms, and minimal interocular differences. Stable waveforms and symmetry were associated with better subjective quality. Shorter MMSE completion time tended to accompany shorter latency and stability, whereas the lowest visual function case showed the longest latency and longer MMSE time.

VEP findings after IOL implantation were distributed within overlapping ranges between multifocal and monofocal eyes and appeared to reflect multiple factors including age, visual performance, optical conditions, and postoperative course. Cases with good visual function tended to show near-normal latency and stable waveform symmetry. These observations may be related to neuroadaptation and visual processing efficiency in postoperative visual performance. VEP characteristics may help to further understand postoperative visual responses and the process of neuroadaptation, although further prospective studies including preoperative assessment are required.