Factors Associated With Fuchs Endothelial Dystrophy: A Population-Based Study In Israel
Published 2025 - 43rd Congress of the ESCRS
Reference: PP25.08 | Type: Free paper | DOI: 10.82333/67jh-6y82
Authors: Farhad Nejat* 1 , Shima Eghtedari 2
1Ophthalmology,Vision health research clinic,Tehran,Iran, Islamic Republic Of, 2Biomedical engineering,Vision health research clinic,Tehran,Iran, Islamic Republic Of
Purpose
To identify potential factors associated with Fuchs endothelial corneal dystrophy (FECD) in Israel.
Setting
A lage scale, poppulation-based study using data from Israel's largest healthcare provider. It insures over 4.7 million people comprising approximately 52% of the population of Israel and is representative of the entire population at large.
Methods
We conducted a cross-sectional study using data from Israel's largest healthcare provider covering the years 2005 to 2023. We identified FECD patients and compared them with age and gender matched controls (1:10 ratio). Demographic factors and comorbidities were analyzed. A multivariable conditional logistic regression model was used to identify independent risk factors associated with FECD.
Results
We identified 591 FECD patients with a mean age of 64.35±11 years; 198 (33.5%) were male. A ten-fold group (n=5910) of age-gender-matched subjects served as controls. Multivariable analysis revealed several factors significantly associated with FECD: Medium and high SES (OR=1.454, p=0.017) and (OR=1.3307, p=0.014), cataract (OR=4.834, p<0.001), skin cancer (OR=1.361, p=0.01), keratoconus (OR=4.346, p<0.002), hyperopia (OR=1838, p<0.01), glaucoma (OR=1.726, p<0.003) and uveitis (OR=3.082, p<0.001).
Conclusions
This population-based study identifies several factors significantly associated with FECD, including medium and high SES, cataract, skin cancer, keratoconus, hyperopia, glaucoma and uveitis. These findings may guide targeted screening strategies and early intervention strategies for FECD patients.