ESCRS - PP09.05 - Comparison Of Horizontal Anterior Segment Biomarkers Measured By As-Oct With Sulcus-To-Sulcus Distance Measured By Ubm

Comparison Of Horizontal Anterior Segment Biomarkers Measured By As-Oct With Sulcus-To-Sulcus Distance Measured By Ubm

Published 2025 - 43rd Congress of the ESCRS

Reference: PP09.05 | Type: Poster | DOI: 10.82333/s0cm-a576

Authors: Ramin Salouti* 1 , Mostafa Nazarpour-Servak 1 , Kia Salouti 2 , Maryam Ghoreyshi 3 , M. Hossein Nowroozzadeh 1

1Ophthalmology Department,Shiraz University of Medical Sciences,Shiraz,Iran, Islamic Republic Of, 2Science Department,The University of British Columbia,Vancouver,Canada, 3Salouti Eye Clinic, Salouti Cornea Research Center,Shiraz,Iran, Islamic Republic Of

Purpose

To evaluate the agreement between horizontal anterior segment parameters—white-to-white (WTW) distance, anterior chamber width (ACW), and anterior chamber angle (ACA)—obtained using the Anterion anterior segment optical coherence tomography (AS-OCT) and the sulcus-to-sulcus (STS) distance measured by Ellex ultrasound biomicroscopy (UBM), the gold standard for intraocular collamer lens (ICL) sizing, to determine which OCT parameter aligns most closely with UBM-STS.

Setting

Salouti Eye Clinic

Methods

A cross-sectional analysis of 110 participants (mean age: 31.0 ± 5.3 years; 66.4% female) was conducted. Horizontal anterior segment morphology was assessed using the Anterion AS-OCT (WTW, ACW, ACA) and Ellex UBM (STS). Statistical analyses included paired t-tests, Bland-Altman limits of agreement (LoA), concordance correlation coefficient (CCC), and Pearson correlation analysis. Only one eye (the right eye) of each participant was included in the analysis.

Results

Among the parameters evaluated, ACW measured by Anterion AS-OCT demonstrated the strongest agreement with Ellex UBM-STS, with a mean difference of 0.06 mm (p = 0.007), a CCC of 0.825 (95% CI: 0.759–0.874), a Pearson correlation coefficient of 0.845 (p < 0.001), and LoA ranging from −0.38 to 0.49 mm. In contrast, ACA and WTW showed slightly weaker concordance: ACA had a mean difference of 0.13 mm (p < 0.001), CCC of 0.769 (95% CI: 0.691–0.823), Pearson r of 0.830 (p < 0.001), and LoA of −0.33 to 0.60 mm. WTW exhibited a mean difference of 0.16 mm (p < 0.001), CCC of 0.757 (95% CI: 0.676–0.819), Pearson r of 0.833 (p < 0.001), and LoA of −0.30 to 0.62 mm.

Conclusions

The Anterion AS-OCT-derived anterior chamber width (ACW) exhibited the smallest bias, narrowest limits of agreement, and highest concordance with Ellex UBM-STS measurements, suggesting its potential as a clinically viable, non-invasive alternative to UBM for ICL sizing. However, according to the LoA analysis, even ACW may differ by up to 0.5 mm from UBM-STS, which could have clinical implications for the interchangeability of these methods.