Corneal Endothelial Cell Changes After Implantable Collamer Lens Implantation In Myopic Patients: A 3 Year Experience
Published 2025 - 43rd Congress of the ESCRS
Reference: PP03.17 | Type: Free paper | DOI: 10.82333/anpt-vb48
Authors: Xiyu Sun* 1 , Wei Wei 2
1The First Affiliated Hospital of Northwest University,Xi'an,China;Shaanxi Provincial Clinical Research Center for Ophthalmology Diseases,Xi'an,China; Xi'an No. 1 Hospital,Xi'an,China, 2Ophthalmology,The First Affiliated Hospital of Northwest University,Xi'an,China
Purpose
This study aimed to assess the long-term alterations in corneal endothelial cells after ICL implantation.
Setting
Oyoun Almadina Center
Methods
We retrospectively reviewed the medical records of 100 myopic patients who underwent ICL implantation (ICL Model V4c; STAAR, Nidau, Switzerland) atOyoun Almadina Center over 3 years follow-up (from May 2021 to May 2024). Specular microscopic parameters (NUM, CD, AVG, SD, CV, and HEX) were collected which was performed using a specular microscope, CEM-530 (Nidek, Aichi, Japan).
Results
As regards the Endothelial cell count (ECC), the median (IQR) cell density was 2764 (2568-2972) cells/mm2 preoperatively, which was decreased to 2751 (2528-2916) cells/mm2 at 6 months post operatively, 2748 (2527-2910) cells/mm2 at 1 year post operatively, 2710 (2519-2898) cells/mm2 at 2 years post operatively, and 2701 (2505 - 2890) cells/mm2 at 3 years post operatively. The difference between the preoperative and each postoperative ECC was not significant statistically (P > 0.05 for all) except for the difference between preoperative and 3 years post operative (P = 0.04).
Conclusions
The long-term follow-up of corneal endothelial cell changes after ICL implantation demonstrates that the procedure is generally safe and does not result in significant endothelial cell loss over time. Although a slight reduction in ECC was observed three years postoperatively, the difference was statistically significant only when compared to preoperative values. These findings highlight the stability of corneal endothelial cells following ICL implantation and support the long-term safety of the procedure for myopic patients