Is Inflammation A Main Target In Keratoconus Pathophysiology? : Lymphocyte To Hdl Ratio (Lhr) And Platelet To Hdl Ratio (Phr) As Serum Inflammatory Indi̇ces May Predict The Progression Of Keratoconus
Published 2025 - 43rd Congress of the ESCRS
Reference: PP02.04 | Type: Free paper | DOI: 10.82333/5b5a-w160
Authors: Myriam Susanne Böhm* 1 , Aaron Kaufman 2 , Francesca Kahale 2 , Pia Leon 2 , Viridiana Kocaba 3 , Ula Jurkunas 2
1Ophthalmology,Schepens Eye Research Institute of Massachusetts Eye and Ear, Harvard Medical School,Boston,United States;Ophthalmology,Massachusetts Eye and Ear Infirmary, Harvard Medical School,Boston,United States;Ophthalmology,Goethe University Clinic,Frankfurt,Germany, 2Ophthalmology,Massachusetts Eye and Ear Infirmary, Harvard Medical School,Boston,United States;Ophthalmology,Schepens Eye Research Institute of Massachusetts Eye and Ear, Harvard Medical School,Boston,United States, 3Ophthalmology,Massachusetts Eye and Ear Infirmary, Harvard Medical School,Boston,United States;Ophthalmology,Schepens Eye Research Institute of Massachusetts Eye and Ear, Harvard Medical School,Boston,United States;Ophthalmology,Singapore Eye Research Institute,Singapore,Singapore
Purpose
Our study aims to evaluate systemic inflammation in patients with keratoconus who have surgical indications for corneal cross-linking using the monocyte to high density lipoprotein cholesterol(HDL) ratio (MHR), neutrophil to HDL ratio (NHR), lymphocyte to HDL ratio (LHR), neutrophil to lymphocyte ratio (NLR), platelet to HDL ratio (PHR).
Setting
Retrospective study
Methods
A total of 103 patients with keratoconus who underwent their first corneal cross-linking surgery between January 2021 and December 2023 and 30 age and sex matched healthy participants were involved in the study.
The preoperative blood samples of the patients were analyzed and laboratory parameters were obtained from hospital records retrospectively.
Results
LHR and PHR values were significantly higher in KC group compared to control group[ 47.57 ± 16.53 vs. 40.83 ± 14.22 (P: 0.045) and 5907.09 ± 1705.56 vs. 5233.90 ± 1379.97 (P: 0.05), respectively].
Although KC patients presented higher mean levels of MHR and NHR than control group no significant differences were achieved. Lower NLR values in KC patients were achieved to compere the control group but differences was insignificant.
ROC analysis demonstrated that LHR and PHR have a good ability to differentiate KC patients from the healthy participants.
Conclusions