Application Of Platelet-Rich Fibrin Membrane Versus Amniotic Membrane Graft Transplantation After Pterygium Excision
Published 2025 - 43rd Congress of the ESCRS
Reference: PO953 | Type: Poster | DOI: 10.82333/krng-yh47
Authors: Taniya Bhoopat* 1 , Nathapon Treewipanon 1 , Tanate Chira-adisai 1 , Sunee Chansangpetch 2 , Surat Saengjinda 3
1Department of Ophthalmology,์Naresuan University,Phitsanulok,Thailand, 2Department of Ophthalmology,Chulalongkorn University,Bangkok,Thailand;King Chulalongkorn Memorial Hospital, Thai Red Cross Society ,Bangkok,Thailand, 3Department of Oral Surgery,์Naresuan University,Phitsanulok,Thailand
Purpose
To compare the efficacy of platelet-rich fibrin (PRF) membrane application versus amniotic membrane graft (AMG) transplantation in preventing recurrence after primary pterygium excision.
Setting
A randomized clinical trial conducted at the eye clinic of Naresuan University Hospital, Phitsanulok, Thailand
Methods
A prospective, single-blinded, randomized clinical trial comparing PRF membrane application and AMG transplantation after pterygium excision by a single surgeon was conducted. Eighty eyes with primary pterygium were randomized into PRF group (40 eyes) and AMG group (40 eyes). Follow-up assessments were conducted at 1 week, 1 month, 3 months, and 6 months postoperatively. The surgical time, pain score, complications, recurrence rate, and 5-fluorouracil (5-FU) injection were evaluated and compared between the two groups.
Results
Patients’ mean age was 62.0 ± 9.2 years. Most of pterygiums were grade 3. Mean surgical duration was similar between both groups (PRF = 37.2 ± 7.6 min, AMG = 36.8 ± 6.2 min; P = 0.81). The pain score was higher in PRF group (4.0 ± 1.9) compared to AMG group (2.5 ± 2.1); (P = 0.001). At 6 months follow up, recurrence was observed in 14 cases (38.9%) in PRF group and 9 cases (23.1%) in AMG group (P = 0.14). Survival analysis showed no significant difference in recurrence (P=0.24). However, better cosmetic results were shown in AMG group (P=0.002). 5-FU injections were done in 32 cases (80%) in PRF group and 17 cases (42.5%) in AMG group (P<0.001). Rate of complications were not significant difference in both groups (P=0.20).
Conclusions
This study showed promising outcome of the use of PRF membrane following pterygium excision. The surgical time, recurrence rate and complication were comparable to AMG with simpler preparation process. However, the patients in PRF group experienced more pain during surgery, needed more 5-FU injections, and had less favorable cosmetic results in terms of grade of recurrence.