ESCRS - PO848 - Safety Of Vivity®, Isopure® And Eyhance®: A Prospective, Double-Blind, Randomised Comparison Between Three Enhanced Depth-Of-Focus Intraocular Lenses

Safety Of Vivity®, Isopure® And Eyhance®: A Prospective, Double-Blind, Randomised Comparison Between Three Enhanced Depth-Of-Focus Intraocular Lenses

Published 2025 - 43rd Congress of the ESCRS

Reference: PO848 | Type: Poster | DOI: 10.82333/vfa2-zn77

Authors: Kristof Vandekerckhove* 1 , Mark Rabinovich 1

1Clinical Study Department,Vista Alpina Eye Clinic,Visp,Switzerland

Purpose

To evaluate the safety of Vivity® (V®), Isopure® (I®) or Eyhance® (E®) IOLs, adopting a mini-monovision approach, in patients undergoing bilateral same-day cataract surgery

Setting

 

Single-center study at Vista Alpina Eye Clinic, Visp, Switzerland.
We here present a substudy within a double-blind, randomized, prospective trial where 280 eyes of 140 patients were bilaterally implanted with Vivity®, Isopure® or Eyhance®, targeting mini-monovision (-0.5D).

Methods

 

We compared the three IOLs based on four safety parameters, assessed between 4-6 months post-surgery:

  1. Monocular corrected distance visual acuity (CDVA)
  2. Binocular uncorrected distance visual acuity (bUDVA) under mesopic conditions
  3. Mesopic contrast sensitivity (CSV-100) at spatial frequencies of 3, 6, 12 and 18 cycles per degree
  4. Photic phenomena as reported in the McAlinden and NEI RQL-42 questionnaires

 

Results

 

CDVA was better for I® (-0.06±0.06 logMAR, p<0.001) and E® (-0.05±0.06, p=0.02) compared to V® (-0.01±0.11).

Mesopic bUDVA was best for E®, followed by I® (p=0.009) and V® (p<0.001): 0.11±0.08, 0.15±0.09, and 0.25±0.1 logMAR respectively.

Mesopic contrast sensitivity favored E® and I® over V®:

-at 12 cpd:  V® 0.76±0.46 log units, I® 0.96±0.40 (p=0.011) and E® 1.01±0.41 (p=0.017).

-at 18 cpd:  V® 0.26±0.26 log units, I® 0.42±0.33 (p=0.014) and E® 0.56±0.36 (p=0.002).

Photic phenomena occured in less than 10% of patients. Specifically, 97%, 95%, and 94% of patients with V®, I®, and E®, respectively, reported never or rarely experiencing glare (ns); 97%, 97%, and 100% never/rarely halos (ns); and 94%, 90%, and 97% (ns) never/rarely starbursts.

Conclusions

 

The findings underscore that all three Enhanced Depth-Of-Focus IOLs — Vivity®, Isopure®, and Eyhance® — maintain a strong safety profile, yet differences in visual acuity and contrast sensitivity especially under mesopic conditions suggest variations in their suitability for specific visual needs. These outcomes emphasize the importance of tailoring lens selection to individual patient needs and preferences in cataract surgery to optimize safety and visual outcomes.