New Customised Xenia Cornea Implant For Moderate And Advance Keratoconus And Post Lasik Ectasia
Published 2025 - 43rd Congress of the ESCRS
Reference: PO590 | Type: Free paper | DOI: 10.82333/236x-d545
Authors: Poppy Debbarma* 1 , Chintan Malhotra 1 , Amit Gupta 1 , Parul Chawla Gupta 1 , Anchal Thakur 1
1Ophthalmology,Advanced Eye Centre,Post Graduate Institute of Medical Education and Research,Chandigarh,India
Purpose
Evaluating the Safety and Efficacy of a Deep Femtosecond Laser Corneal Pocket with Implanted NEW Customized Decellularized Porcine Corneal Lenticule and Collagen Corneal Ring in Treating Moderate to Advanced Keratoconus and Post-LASIK Ectasia
Setting
In this study, the implantation was performed on fifteen eyes across fifteen patients with advanced keratoconus. The lenticules and the cornea ring are extracted from porcine tissue, which is subjected to a decellularisation process, intensely cross linked, sterilised, and packed. Lenticule is 44 +/-5 microns thickness and a diameter of 7.5 to 8.0mm, the collagen ring Outer diameter: 7.8mm Inner diameter: 5.6mm Angle: 150 degrees Thickness: Approx. Via Femto laser constructed pocket in deep
Methods
In this study, the implantation was performed on five eyes across five patients with advanced keratoconus. These patients had previously undergone corneal collagen cross-linking more than one year before. One patient underwent corneal cross-linking two weeks before the insertion of the inlay. The lenticules are extracted from porcine tissue, which is subjected to a decellularisation process, intensely cross linked, sterilised, and packed. is 44 +/-5 microns thickness and a diameter of 7.5 to 8.0mm. A modified technique was used to insert the device into a manually constructed pocket in the posterior corneal stroma.
Results
The modified technique of posterior corneal stromal implantation with pocket creation via Femto laser in combinationwith Implanted NEW Customized Decellularized Porcine Corneal Lenticule and Collagen Corneal Ring with anterior corneal collagen cross-linking is safe and results in significant improvements in the following corneal parameters: Central corneal thickness increased from 429 +/-22.19 to 463 +/- 21.89, the maximum keratometry decreased from 63.4 +/-7.73 to 49.92 =/+2.37, and total higher-order aberrations decreased from 3.0778 +/-1.2 to 1.8924 +/-0.379, decreasing Keratoconus staging from 3-4 to 1-2, and improving patient vision and astigmatism.
Conclusions