Evaluation Of Epi-Off Accelerated Corneal Collagen Crosslinking In Patients Affected By Progressive Keratoconus: 1 Year Follow Up

to investigate efficacy, safety, and outcomes after epi-off accelerated (30 mV/cm2) corneal collagen crosslinking (ACCC) in eyes affected by progressive keratoconus (KC) after 1 year of treatment. 

Università degli Studi della Campania Luigi Vanvitelli, Napoli, Italy.

ACCC procedures were performed in 51 progressive KC eyes of 40 patients with a mean age of 23.8 ± 5.19 years (ranging from 15 to 36 years). A complete eye visit including visual acuity and intraocular pressure evaluation measurements, slit lamp evaluation, Scheimpflug camera scan providing anterior and posterior corneal curvature and corneal thickness were performed at baseline and at 1, 3, 6 and 12 months follow up. Mean anterior (AMK) and posterior (PMK) keratometry, anterior maximus keratometry (Kmax), thinnest corneal point (TCP) changes were evaluated with Paired Student T Test.

after 1 year of ACCC, no significant variations were observed in AMK (-0.06 ± 0.61 D), PMK (-0.04 ± 0.11 D) and TCP (-2.33 ± 11.21). No complications were detected in every patient treated and best corrected distance visual acuity (BCDVA) was stable (mean change: -0.03 ± 0.14 logMAR, p= 0.07) at 1 year follow up.

according to data observed in this study, even if they need to be confirmed in larger population and longer follow up, ACCCusing an energy of 30 mV/cm2 could be a safe and effective procedure aiming to stabilize the clinical conditions of eyes affected by progressive KC.