Efficacy Of Home-Based, Virtually Guided Bynocs® Dichoptic Therapy In Amblyopia Treatment

To evaluate the effectiveness of BYNOCS® home-based, virtually guided dichoptic therapy in improving visual acuity and stereopsis in anisometropic and isometropic amblyopia, including patients beyond the critical period of visual plasticity.

Home, Web Based ,Virtual Session

This cohort study included 625 subjects (mean age: 18±15 years) diagnosed with anisometropic or isometropic amblyopia, all of whom had undergone full-time spectacle correction. Patients with deprivation amblyopia, ocular comorbidities, or neurological deficits were excluded. Therapy was administered remotely through the BYNOCS® platform, consisting of 30-minute dichoptic game-based exercises, five days a week. The therapy utilized differential contrast presentation—higher contrast stimuli to the amblyopic eye and lower contrast to the non-amblyopic eye—to facilitate balanced binocular integration.

• Visual Acuity Gains: Participants showed an improvement of 3 LogMAR lines, with average visual acuity improving from 0.40±0.20 to 0.10±0.00 LogMAR (p < 0.0001).
• Stereopsis Recovery: Among 191 subjects with no stereopsis, 139 (73%) developed measurable depth perception post-therapy. The average stereopsis improvement was 315±360 sec of arc.
• Efficacy Beyond Critical Age: Significant improvements were observed across all age groups, demonstrating that binocular engagement can drive neural plasticity even beyond the traditional monocular critical period.

Home-based, virtually guided BYNOCS® dichoptic therapy is an effective and accessible treatment for amblyopia, offering sustained improvements in both visual acuity and stereopsis. Unlike traditional patching, this approach harnesses binocular integration and neuroplasticity, yielding results beyond the conventional age limit for amblyo