The Impact Of Soft Contact Lenses On The Corneal Neuromediators And Optical Quality In High Myopia
Published 2025 - 43rd Congress of the ESCRS
Reference: PO1036 | Type: Poster | DOI: 10.82333/4f42-1s58
Authors: Jun Zou* 1 , Yuhao Shao 1 , Min Li 1 , Wei Wang 1 , Yuehui Shi 1 , Yiyong Qian 1
1Department of Ophthalmology,Shanghai Tenth People’s Hospital,Shanghai,China
Purpose
To investigate the impact of long-term soft contact lenses (SCLs) wear on corneal neuromediators in stromal lenticules and optical quality.
Setting
The retrospective cohort study recruited patients with high myopia who underwent Small Incision Lenticule Extraction.
Methods
140 eyes of 70 high myopia patients were divided into three groups based on duration of wearing SCLs: > 10 years group, ≤ 10 years group, and NW group. Corneal higher-order aberrations and densitometry were assessed using a Pentacam system. Neuromediator levels in stromal lenticules were analyzed using ELISA and immunofluorescence.
Results
The levels of NGF, SP, and MANF significantly increased in SCLs wearers. Compared to the NW group, corneal densitometry values within the 0-6mm zone were obviously higher in both the ≤ 10 years and > 10 years group. The total higher-order aberrations and horizontal coma were elevated in the > 10 years group. Significant correlations were found between MANF and horizontal trefoil, as well as IGFBP-1 and horizontal coma in the ≤ 10 years group. In the > 10 years group, all these neuromediators positively correlated with densitometry within the anterior and posterior layers of the 0-6 mm zones. For the ≤ 10 years group, NGF and CGRP displayed positive correlations with densitometry in the anterior, posterior, and total layer.
Conclusions
The prolonged SCLs wear with high myopia may lead to an elevation of cornea stromal neuromediators levels and a decline in corneal optical quality.