Glistenings Formation In Hydrophobic Acrylic Intraocular Lenses And Modification Strategies
Published 2025 - 43rd Congress of the ESCRS
Reference: FP17.07 | Type: Free paper | DOI: 10.82333/wyz4-kf47
Authors: Maria A. Henriquez* 1 , Gustavo Menares 2 , Jose Daniel Altamirano 2 , Rolando Rojas 2 , Jose Chauca 3 , Luis Izquierdo Jr 4
1Research Department,Oftalmosalud Institute of Eyes,Lima,Peru;Faculty of Human Medicine,Universidad Ricardo Palma,Lima,Peru, 2Research Department,Oftalmosalud Institute of Eyes,Lima,Peru, 3Research Department,Oftalmosalud Institute of Eyes,Lima,Peru;Department of Statistics, Demography, Humanities and Social Sciences,Universidad Peruana Cayetano Heredia,Lima,Peru, 4Research Department,Oftalmosalud Institute of Eyes,Lima,Peru;San Fernando School of Medicine,Universidad Nacional Mayor de San Marcos,Lima,Peru
Purpose
To evaluate the morphology of different hydrophobic acrylic IOLs, nalyze the formation of glistenings and their impact on optical performance.Discuss the mechanism of glistenings formation and propose modification strategies.
Setting
An in vitro laboratory study.
Methods
Four IOLs from different manufacturers were analyzed: SN60WF (Alcon), SY60WF (Alcon), ZCB00 (Johnson & Johnson), and ASOB55L (Century Healthcare).Induce glistenings in different IOLs through accelerated aging experiments, and evaluate the degree of IOL glistenings using a zoom stereo microscope. Assess the surface morphology of IOLs with Atomic Force Microscopy (AFM), and measure the contact angle of IOLs . Measure the Strehl ratio and Modulation Transfer Function (MTF) using standard metrology equipment . Analyze the structure of IOLs with Fourier Transform Infrared Microspectroscopy. Through the above examinations, analyze the anti-glistening mechanisms of different IOLs and discuss their modification strategies.
Results
The central part of the IOL optic had a higher number of glistenings compared to the periphery.AcrySof IQ SN60WF had the highest average number of MV in the central part, with 46.40 (±20.61) MV/mm². ZCB00 with 3.20±2.95 MV/mm². ASOB55L with 1.60±1.77 MV/mm². The lowest number ofglistenings was obtained averaging the SY60WF IOLs, with 1.19±0.77 MV/mm². Statistical analysis showed that glistenings in all IOL groups had no significant impact on optical quality.
Conclusions
The AFM analysis and surface contact angle measurements of all IOLs tested showed that the Mercury ASOB55L IOL and Clareon SY60WF IOL had the best topographic features. The smoother, more regular surface of these new IOL models might reduce cell adhesion and therefore lower the incidence of posterior capsule opacification. The glistening of all IOLs has no effect on optical quality. Appropriately increasing the hydrophobicity of the material or introducing a certain amount of hydrophilic groups to balance the hydrophilicity and hydrophobicity may help reduce the occurrence of glistening. They showed superiority in its glistening density result compared to the Acrysof SN60WF IOL.