ESCRS - FP12.14 - The Distribution Of Lens Structure Parameters And Influencing Factors In Patients With Age-Related Cataract

The Distribution Of Lens Structure Parameters And Influencing Factors In Patients With Age-Related Cataract

Published 2025 - 43rd Congress of the ESCRS

Reference: FP12.14 | Type: Free paper | DOI: 10.82333/6yts-td39

Authors: Burak Tanyıldız* 1 , Fatma I. Sozen Delil 1 , Erdi Karadağ 1

1Ophthalmology,Kartal Doctor Lütfi Kırdar City Hospital,İstanbul,Türkiye

Purpose

This study aimed to explore the potential associations between the measured lens structure parameters in patients with age-related cataract and such variables as age, gender, and ocular biometric parameters.

Setting

A cross-sectional study

Methods

Patients with cataract aged 40 and older were included. The three-dimensional structure parameters of the lens, including radius of anterior lens surface curvature (RAL), radius of posterior lens surface curvature (RPL), lens thickness (LT), anterior lens thickness (LTa), lens diameter (LD), and lens volume (LV), were measured and calculated via Swept-Source Anterior Segment Optical Coherence Tomography (SS-AS-OCT) and Digimizer. The correlations between these lens parameters and patient age, gender, and ocular biometric parameters such as axial length (AL), mean keratometry (Km), anterior chamber depth (ACD), and horizontal corneal diameter (white to white, WTW) were analyzed.

Results

This study enrolled 140 patients (140 eyes), with a mean age of 65.586±8.756 years (range: 41-83 years). Among them, 40.0% (56 cases) were male, and 60.0% (84 cases) were female. It was found that the RAL in males was lower than that in females (p< 0.05). LT, LTa, and LV showed statistically significant differences across age groups (p<0.05). Among these, LT showed a positive linear correlation with age (R=0.277, p=0.001). RAL was positively correlated with AL (R=0.235, p=0.005) and ACD (R=0.445, p=0.000). In contrast, LT (R= -0.686, p=0.000), LTa (R= -0.597, p=0.000), LD (R= -0.257, p=0.002), and LV (R= -0.486, p=0.000) showed negative correlations with ACD. Km and WTW showed no significant correlation with the lens parameters (p> 0.05).

Conclusions

With increasing age, the LT parameter shows a linear increase, while LTa and LV parameters exhibit a nonlinear pattern, initially increasing and then decreasing. Changes in ACD affect lens parameters more significantly than other factors. Cataract patients with deep anterior chambers tend to have a larger RAL, as well as smaller LT and LV.