Quantitative Analysis Of Anterior Chamber Inflammation Before And After Cataract Surgery

Published 2025 - 43rd Congress of the ESCRS

Reference: FP12.05 | Type: Free paper | DOI: 10.82333/v2we-0t69

Authors: Stephen Morgan* ¹ , Yarrow Scantling-Birch ²

¹Sussex Eye Hospital,Brighton,United Kingdom, ²Moorfields Eye Hospital,London,United Kingdom

Purpose

To assess subclinical inflammation measured with a noninvasive method to quantify anterior chamber (AC) inflammation in patients underwent cataract surgery.

Setting

Eye Clinic, University of Brescia

Methods

The number of hyper-reflective dots representing AC cells and optical density ratio (aqueous-to-air relative intensity [ARI] index) for flare quantification were calculated from AS-OCT images. ARI index and AC cells were calculated in eye that had cataract surgery, before (T0), after 2 hours (T1) and the second day (T2). The values were compared with a control group represented by the fellow eye.

Results

Fifty-two eyes of 26 patients were included. ARI index and AC cells were significantly higher after the surgery in the eyes underwent cataract surgery than the control group. For the entire group of cataract patients, AC cells increased from the baseline value of 2.6 cells (1.6–3.9) to 10.7 cells (4.6–19.6) at T1 (p<0.0001). No differences were detected from the baseline value of 2.6 cells (1.6–3.9) to 4.0 cells (2.8–7.6) at T2 (p>0.05). The ARI index was significantly higher from the baseline value of 81.5 (64.0–94.0) to 136.9 (102.7–199.7) at T1 (p<0.0001) and to 109.1 (85.1–139.2) at T2 (p=0.03) respectively. No statistical differences were detected in the control group for ARI index and AC cells during the observation period (p>0.05).

Conclusions

AS-OCT system may be used to detect inflammation through a noninvasive method to quantify AC inflammation in eyes underwent cataract surgery.