10-Year Effectiveness And Safety Outcomes Of Ab-Interno Canaloplasty In Open-Angle Glaucoma

To evaluate the 10-year effectiveness and safety outcomes of ab-interno canaloplasty in patients with open-angle glaucoma (OAG).  

retrospective, single-center case series 

This retrospective, single-center case series included 27 eyes of 22 patients with primary open-angle glaucoma (POAG) or pseudoexfoliative glaucoma (PEX) who underwent ab-interno canaloplasty using the iTrack (Nova Eye Medical, Fremont, USA) microcatheter mostly combined with cataract surgery (23 out of 27 eyes), between October 2014 and October 2016. Primary endpoints included changes in mean intraocular pressure (IOP) and mean number of glaucoma medications over time. 

At a mean follow-up of 75.1±33.7 months, mean IOP decreased significantly from 19.9±5.2 mmHg at baseline to 14.9±3.9 mmHg (-25%; p<0.001), and mean medication use reduced from 1.9±1.0 to 1.0±1.1 (-47%; p=0.006). Visual field mean deviation (VF MD) remained stable (-8.14±6.93 dB to -7.17±7.45 dB; p=0.623). Among the four eyes followed for 10 years, mean IOP decreased from 20.0±4.1 mmHg to 14.5±2.1 mmHg (-28%), while medication use remained stable (2.0±1.2 to 2.0±0.8). No serious complications or need for additional glaucoma surgery were reported in this subgroup.  

Ab-interno canaloplasty with the iTrack microcatheter demonstrated sustained reductions in IOP and medication use up to 10 years postoperatively, with a favorable safety profile. These findings represent the longest reported follow-up data for ab-interno canaloplasty in the literature.