ESCRS - FP02.02 - Eight-Year Results Of Laser In-Situ Keratomileusis With Or Without Combined Accelerated Cross-Linking In High Myopic Eyes

Eight-Year Results Of Laser In-Situ Keratomileusis With Or Without Combined Accelerated Cross-Linking In High Myopic Eyes

Published 2025 - 43rd Congress of the ESCRS

Reference: FP02.02 | Type: Free paper | DOI: 10.82333/pvxd-7v03

Authors: Ana Miguel* 1 , Quentin Bosredon 2 , Alice Grise Dulac 3

1Ophthalmology,Central University Hospital Caen,Caen,France;Ophthalmology,Private Hospital of La Baie,Avranches,France, 2Ophthalmology,Clinique Thiers,Bordeaux,France, 3Ophthalmology,Fondation Ophtalmologique Adolphe de Rothschild,Paris,France

Purpose

To investigate the long-term results of femtosecond laser-assisted in situ keratomileusis (FS-LASIK) combined with accelerated corneal crosslinking (LASIK-Xtra) compared to conventional FS-LASIK (convLASIK) in highly myopic eyes.

Setting

Department of Ophthalmology, Goethe-University, Frankfurt, Germany.

Methods

A prospective, randomized fellow eye-controlled clinical trial. Patients who received randomized treatment with the LASIK-Xtra (30mW/cm2, 90sec with continuous UVA) in one and convLASIK in the fellow eye were subjected preoperatively, 1 (pos1y) and 8 years postoperatively (pos8y) to subjective refraction, uncorrected (UDVA) and distance-corrected visual acuity (DCVA), endothelial cell count (ECC), biomechanical evaluation, and tomographic examination.

Results

26 eyes (-7.07±1.86 D) from 13 patients (30.7±10.4 years) were included. UDVA and DCVA were insignificant different at pos1y and pos8y (each p>0.28). Safety index at pos8y was 1.09 for convLASIK and 1.15 for LASIK-Xtra (p=0.799), and the efficacy index 0.91 and 0.94 (p=0.875), respectively. Myopic regression in spherical equivalent between pos1y (-0.30±0.40D) and pos8y (-0.80±0.86D) was found in the convLASIK group (p=0.018), compared the LASIK-Xtra group (-0.25±0.49D and -0.40±0.86D; p=0.261), respectively. Insignificant differences in mean keratometry, corneal thickness, and ECC were found at pos8y (p>0.05). Stress-strain index was the only biomechanical parameter that was significantly higher in the LASIK-Xtra group at pos8y (p=0.034).

Conclusions

After 8 years, no substantial disparities in efficacy and safety were observed between the two groups. LASIK-Xtra showed a lower myopic regression. The postoperative cornea tended to become slightly stiffer in the LASIK-Xtra group; however, further studies with larger sample sizes are necessary to validate this finding.