Comparative Evaluation Of Biomechanical Changes And Aberration Profile Following Accelerated Collagen Cross Linking Using Hypo-Osmolar And Iso-Osmolar Riboflavin: A Prospective Study
Published 2024 - 42nd Congress of the ESCRS
Reference: PP23.04 | Type: Free paper | DOI: 10.82333/352c-2w48
Authors: Manumuraleekrishna Manumuraleekrishna* 1 , Mohamed Ibrahime Asif 2 , Ritu Nagpal 2 , Namrata Sharma 1
1Ophthalmology,RPC, AIIMS,New Delhi,India, 2Ophthalmology,Eye 7 hospital,New Delhi,India
Purpose
To compare the changes in corneal biomechanics and aberration profile following accelerated corneal collagen cross-linking (CXL) using hypo-osmolar and iso-osmolar riboflavin in corneal thickness <400 and >400 microns respectively
Setting
Prospective, interventional, comparative study
Methods
This is a prospective, interventional, comparative study involving 100 eyes of 75 patients with progressive keratoconus. Eyes were divided into two groups based on corneal thickness: Group-1 included eyes with corneal thickness <400 microns who underwent hypo-osmolar CXL and Group-2 included eyes with thickness >400 microns who underwent iso-osmolar CXL. Corneal biomechanical and aberration profiles were evaluated and compared between groups.
Results
In group 1, all higher-order aberrations (HOA) except secondary astigmatism significantly decreased from baseline; however in group 2 only coma and trefoil decreased. The corneal resistance factor (CRF) and corneal hysteresis (CH) significantly improved in both groups, which was significantly greater in group 2 than in group 1. The change in Inverse Radius, Deformation Amplitude and Tomographic Biomechanical Index (TBI) was significantly improved in group 2 as compared to group 1.
Conclusions
Improvement in corrected distance visual acuity (CDVA) and decrease in HOA were significantly better in the hypo-osmolar CXL group; however, the improvement in biomechanical strength of the cornea was significantly better in the iso-osmolar group