Visual Performance Of An Extended Depth Of Focus Intraocular Lens In Eyes With Low To Moderate Irregular Astigmatism – An Interims Analysis

To test monocular and binocular far and intermediate vision in patients with low to moderate irregular astigmatism receiving an enhanced depth of focus (EDOF) intraocular lens (IOL). 

Medical University of Vienna

Patients with irregular astigmatism exhibiting an anterior root mean square (RMS/a) of 0.3µm/mm² or higher in the 3.0 mm zone in at least one eye were included in the study. Irregular astigmatism was measured using an anterior segment OCT MS-39 (CSO, Firenze, Italy). All patients received either a monofocal Acrysof Vivity DFT015 or toric DFT215-615 IOL if the total astigmatism was more than 0.75 diopters (D). Monocular and binocular best-corrected distance visual acuity (BCDVA), monocular distance-corrected intermediate visual acuity (DCIVA) at 66cm and monocular distance-corrected near visual acuity (DCNVA) at 40cm were assessed using ETDRS charts at 4 months (4m). Monocular defocus curves were assessed at 4m.

Ten patients including 20 eyes were assessed for the interims analysis. Mean preoperative RMS/a was 0.035±0.007µm/mm². Monocular BCDVA at 4m for the study eye was -0.03±-0.05 logMAR. Binocular BCDVA was -0.09±0.06 logMAR. Monocular DCIVA was 0.19±0.1 logMAR. Monocular DCNVA was 0.36±0.06 logMAR. 

Patients exhibiting low to moderate irregular astigmatism showed very good postoperative monocular and binocular distance visual acuity below 0.0 logMAR. Accordingly, intermediate and near vision showed similar results using an EDOF IOL. Low to moderate irregular astigmatism is not an exclusion criterion for Vivity EDOF IOL implantation.