Correlation Between Corneal Biomechanics And The Progression Of Refractive Status In Teenagers – A Portuguese Cohort From The Oporto Myopia Study
Published 2024 - 42nd Congress of the ESCRS
Reference: PP18.01 | Type: Free paper | DOI: 10.82333/hs96-ey61
Authors: João Ponces Ramalhão* 1 , João Heitor 1 , Paulo Sousa 1 , Saúl Pires 1 , Renato Ambrósio 2 , Pedro Menéres 1 , João Beirão 1 , Pedro Baptista 1
1CHUdSA,Porto,Portugal, 2UNIRIO,Rio de Janeiro,Brazil
Purpose
Our purpose is to describe corneal baseline biomechanics and progression of the refractive status in a cohort of portuguese teenagers and to correlate both parameters during the follow up.
Setting
Centro Hospitalar e Universitário de Santo António, Porto, Portugal
Methods
This is a prospective cohort study including 126 eyes of 63 individuals. Data was collected from 2 timepoints, spaced by 2.4(+-0.3) years.
Corneal biomechanics were assessed in the baseline visit with Corvis ST (OCULUS, Germany) and parameters assessed included Corvis Biomechanic Index (CBI), tomographic and biomechanic index (TBIv1 and TBIv2), data from Whole Eye Movement at the time of maximum concavity (WEMmax) and Stiffness parameters in A1 and in highest concavity (SP-A1 and SP-HC).
Objective refractive status was assessed using KR-800 Auto Kerato-Refractometer (TOPCON, Japan).
Delta of progression was built for absolute Spherical Equivalent (Δ_SE).
Correlations were addressed between ocular biomechanics and Δ_SE.
Results
The present study included 126 eyes from 63 individuals, with a mean age at baseline of 14.2(+-2.6) years old.
Variaton of spherical equivalent (Δ_SE) was correlated with biomechanical parameters:
Whole Eye Movement Max [mm] (Pearson 0.246 p<.01; Spearman 0.196 p<.05); Whole Eye Movement Max [ms] (Pearson 0.372 p<.001; HC dArc Length [mm] (Pearson 0.197 p<.05; Spearman 0.225 p<.05); DA Ratio Max (2mm) (Pearson 0.185 p<.05; Spearman 0.234 p<.01); DA Ratio Max (1mm) (Pearson 0.205 p<.01; Spearman 0.211 p<.05); ARTh (Pearson -0.29 p<.01; Spearman -0.302 p<.001); Integrated Radius [mm^-1] (Pearson 0.348 p<.001; Spearman 0.27 p<.01); CBI (Pearson 0.239 p<.01; Spearman 0.281 p<.05); TBIv1(Spearman 0.207 p<.05); TBIv2(Spearman 0.211 p<.05)
Conclusions
The present study reports the association of ocular biomechanics analysis by means of Scheimpflug image with changes in refractive status in teenagers. This could pave the way for the creation of a biomechanical algorithm that could help in the prediction of myopia progression in the young. These data are important to help design effective strategies for the prevention of the global myopia epidemic in the upcoming decades.