Halting Progressive Presbyopia: Laser Microporation Uncrosslinking For Restoring Ocular Biomechanics

To simulate the biomechanical chain of events involved in Dynamic Range of Focus including accommodation and disaccommodation.

Small Business Innovation Research (SBIR) grant application experimental study

Finite element modeling was used to demonstrate the movements of the crystalline lens through three phases: 1) pre-stretch of the crystalline lens  2) accommodation, 3) disaccommodation.  Biomechanical forces within these phases are illustrated using computer modeling.   

Disaccommodation was demonstrated, illustrating the importance of Bruch’s membrane choroid complex (BMCC). Forces upon the ciliary muscles as the lens moves through the three phases are modeled based on previously published anatomical imaging. The mechanical impact of aging upon DRoF is also demonstrated.  New insights of posterior pole of the lens moving posteriorly during accomomodationand contributoig to ciliary muscle movement through elastic forces of the BMCC are presented. 

Demonstrating forces involved in disaccommodation using computer modeling was successful.    An increased understanding of the biomechanics of disaccommodation and its role in DRoF is beneficial when considering the rejuvenation of presbyopia.