Comparison Of Clinical And Patient Reported Outcomes In Patients With Age-Related Macular Degeneration Implanted With An Enhanced Or A Standard Monofocal Iol

To compare the clinical and patient reported outcomes of a new TECNIS Eyhance (ICB) monofocal IOL to a conventional TECNIS One (ZCB) monofocal intraocular lens in a sample of patients with age-related macular degeneration.

Private Refractive Surgery (Optical Express)

Patients with early to moderate dry AMD who underwent intraocular surgery with either TECNIS Eyhance (ICB) monofocal, n=36 patients, 60 eyes, or conventional TECNIS One (ZCB) monofocal IOL, n=131 patients, 195 eyes, were analyzed. Both cohorts were well matched based on demographic and preoperative parameters. Patient age range was 48 to 96 years, with a preop refractive range of +9.50D to -9.75D sphere and up to -1.75D of astigmatism. Postoperative clinical safety and efficacy outcomes up to 12 months, with a mean of 3 months, following implant were analyzed.

UCDVA 20/20 or better in 53% of ICB patients, 47% in ZCB (p=0.56), 94% ICB and 85% ZCB had 20/40 or better (p=0.13). UCIVA 20/40 or better in 63% ICB, 36% ZCB (p=0.01). UCNVA N8 or better in 42% ICB patients, 15% ZCB (p<0.01). 5% ICB eyes had loss of >2 lines BCVDA, 0% ZCB (p<0.01). Mean difference between postop UCDVA and BCVDA was <1 line for both cohorts (p>0.05). Intended vs achieved SE ±0.5D was 86% for ICB and 81% for ZCB (p>0.05); ±1.0D was 92% and 97% (p>0.05). Intended vs achieved cylinder ±0.5D was 66% for ICB and 53% for ZCB (p>0.05); ±1.0D was 88% and 86% (p>0.05). Patient reported satisfaction was high for both cohorts (p=0.38), and Quality of vision questionnaire showed comparable outcome between cohorts (p=0.78).

The TECNIS Eyhance (ICB) provides a safe and effective monofocal IOL option for patients with early to moderate dry AMD. UCDVA performance is comparable to a standard monofocal lens at distance with meaningful improvements to UCIVA and UCNVA. The loss of > 2 lines BCDVA is impacted upon by both the small sample size and posterior capsular opacification. Patient reported satisfaction is high postoperatively for both lens options with comparable reporting of Quality of Vision difficulty.