Comparison Meta-Analysis Of Two Swept-Source Optical Coherence Biometers

This systematic review and meta-analysis aimed to evaluate the comparability of two swept-source optical coherence tomography (SS-OCT) biometers, Anterion and IOLMaster 700.

General University Hospital of Elche, Spain.

Articles published until October 1, 2023 were reviewed. Eligibility criteria included a comparative study design, absence of ocular diseases except cataract or refractive errors, same day measurements with both devices, and outcomes such as axial length, mean keratometry, astigmatism vectors, anterior chamber depth, central corneal thickness, lens thickness, corneal diameter, white-to-white, and intraocular lens power for emmetropia.

This systematic review incorporated 17 studies (2943 eyes). The mean difference (MD) of axial length measurements obtained with Anterion and IOLMaster 700 was -0.01 [-0.09; 0.06].  Anterion provided significantly larger anterior chamber depth (0.10 mm [0.08 - 0.12 mm]) and lens thickness (0.04 mm [0.01; 0.07]), while IOLMaster 700 had significantly larger white-to-white measurements (0.20 mm [-0.24; -0.16]). Corneal measurements tend to be flatter for Anterion, although no significant differences were found between devices.

This meta-analysis showed statistically significant differences in WTW, LT and ACD measurements between devices. AL measurements were comparable between biometers. Anterior mean, steep and flat keratometry tend to be higher with IOLMaster700. These differences may result in a higher IOL power for emmetropia when data is entered from Anterion measurements. Thus, measurements from both devices should not be considered interchangeable. Future studies will be needed to establish the influence of these differences on the refractive predictability of IOL power calculation.