Effect Of Postoperative Topical Nepafenac On Pupil Dynamics After Cataract Surgery
Published 2024 - 42nd Congress of the ESCRS
Reference: PP04.05 | Type: Free paper | DOI: 10.82333/edak-d721
Authors: Serdar Bilici* 1 , Mehmet Şahin 2 , Numan Küçük 2 , Suat Hayri Uğurbaş 2
1Ophthalmology,Zonguldak Bülent Ecevit University,Zonguldak,Türkiye;Ophthalmology,Zonguldak Bülent Ecevit University,Zonguldak,Türkiye, 2Ophthalmology,Zonguldak Bülent Ecevit University,Zonguldak,Türkiye
Purpose
To evaluate the effect of topical nepafenac therapy on changes in pupil dynamics after cataract surgery
Setting
Department of Ophthalmology, Bülent Ecevit University, Zonguldak, TURKEY
Methods
A prospective randomized study. Fifty eyes of 50 patients undergoing routine cataract surgery by the same surgeon were randomized 1:1 for postoperative topical 0.3% nepafenac therapy (NSAID+ group) in addition to combined 0.5% moxifloxacin and 0.1% dexamethasone formulation (NSAID- group). Clinical parameters and level of ultrasound used (cumulative dissipated energy, CDE) were recorded. Pupil diameters were measured before, 1 week, and 1 month after the surgery in static scotopic, mesopic, and photopic pupil conditions.
Results
The mean CDE value was 9.28±6.05 in the whole group. The only significant change in the mean pupil diameter was observed in scotopic condition (4.92±1.05, 4.42±0.79 and 4.56±0.72 mm at the 0th day,1st week and 1st month, respectively,p<0.001).No significant correlation between CDE and scotopic pupil diameter (SCP) changes was observed (r:0.02).The means of SCP at the beginning, 1st week, and 1st month were 4.90 ± 0.91, 4.57 ± 0.69, and 4.61 ± 0.70 in the NSAID+ group (p=0.17) and 4.94±1.25, 4.22±0.90 and 4.49±0.78 in the NSAID- group (p=0.002), respectively.There was a greater decrease in SCP in the NSAID- group (5.9%vs13.3%,p=0.027) at the 1st week.The rate of decrease in SCP becomes similar at the 1st month (5.1%vs6.9%,p=0319).
Conclusions
Phacoemulsification cataract surgery leads to a decrease in scotopic pupil diameter. Postoperative additional topical nepafenac therapy provides a lesser rate of change in pupil diameter in the short term.