Keratoconus Family Screening For Studying Prevalence In 1St-Degree Relatives With Corneal Topography
Published 2024 - 42nd Congress of the ESCRS
Reference: PP01.05 | Type: Free paper | DOI: 10.82333/3bs5-zg53
Authors: Anuja J* 1 , Lokeshwari Aruljyothi 2 , Manoharbabu B 3
1cornea , refractive surgery and cataract ,Aravind eye hospital,Salem,India, 2cornea , refractive surgery and cataract ,Aravind eye hospital,Salem,India;cornea , refractive surgery and cataract ,Aravind eye hospital,Salem,India, 3cataract ,Aravind eye hospital,Salem,India
Purpose
Keratoconus has multifactorial etiology . genetic involvement has not been clearly defiined . there is a prevalence of keratoconus and its traits amongst siblings have been documented but its data is meagre. This study aims in identifying whether there are findings suggestive of subclinical keratoconus amongst first degree relatives like parents , siblings and children of keratoconus patients
Setting
A prospective case control cohort observational study in a tertiary eye hopstial in South India
Methods
First-degree family members of 29 keratoconus-diagnosed patients were invited to undergo Orbscan topography.Study period- 6 months from July 2023 to December 2023. Inclusion criteria - Parents and siblings of kertocunus patients .Exclusion criteria - participants with previous history of ocular trauma , surgery , keratoplasty , or corneal scarring .22 families consented, yielding 59 topographies.These topographies were analyzed in detail using topography parameters like k max , irregularity in the 3 mm and 5 mm zone,skewing , height of posterior float , central corneal thickness, difference between central and peripheral corneal thickness. Theses datawere analysed using STATA 17.0, was compared via chi-square and Mann whitney tests.
Results
Prevalence of keratoconus and kertoconus traits wer observed in 54 % of the participants , Of these 39 % of them had keratoconic traits and 15% had keratoconus , Limitation - Not all
first-degree relatives could be screened andlargersample size would be neededto extrapolate to general population.
Conclusions
This study shows the prevalence of keratoconus and and its traits amongst first degree relatives . This not only contributes to the scientific understanding of keratoconus but also serves as a platform for educating families about the conditions, familial nature, the importance of early detection, and potential preventive actions. This knowledge empowers families to take proactive steps to manage and reduce the impact of keratoconus.