Systematic Review And Meta-Analysis On The Incidence Of Sympathetic Ophthalmia Following Glaucoma Surgery
Published 2024 - 42nd Congress of the ESCRS
Reference: PO970 | Type: Poster | DOI: 10.82333/92zq-vv47
Authors: Bonnie He* 1 , Mohamed Bondok 2 , Brendan Tao 3 , Mostafa Bondok 3 , Ahsen Hussain 1 , Edsel Ing 4
1Department of Ophthalmology ,Dalhousie University,Halifax,Canada, 2Department of Ophthalmology ,University of Calgary,Calgary,Canada, 3Department of Ophthalmology ,University of British Columbia,Vancouver ,Canada, 4Department of Ophthalmology ,University of Alberta,Edmonton,Canada
Purpose
Sympathetic ophthalmia (SO) is a rare bilateral granulomatous panuveitis that can present after trauma or intraocular surgery (IOS). The incidence of SO after IOS varies among studies in the literature. The purpose of this review was to determine the incidence proportion of SO after IOS overall, and of glaucoma surgeries specifically.
Setting
Systematic review and meta-analysis
Methods
MEDLINE, EMBASE, and Cochrane databases were searched from inception to January 2023 for population-based studies of SO after IOS. Two reviewers independently screened the results. Random-effects meta-analyses calculated incidence proportion. A subgroup analysis of glaucoma surgeries was also conducted to assess the incidence of SO following all glaucoma surgeries. Study quality and bias were assessed using the Newcastle-Ottawa scale and the Grades of Recommendation, Assessment, Development, and Evaluation framework.
Results
The final meta-analyses included 19 studies, with 118 cases of SO occurring after 505 178 inciting events. The estimated overall incidence proportion of SO after IOS was 0.061% (95% confidence interval [CI], 0.033%–0.111%; I2 = 83%) and the estimated incidence rate was 9.24 cases per 100 000 person-years (95% CI, 4.03–21.19; I2 = 88%). The average study duration across these studies was 10.8 years. The incidence proportion of SO following glaucoma surgeries was 0.098% (95% CI, 0.042%–0.232%; I2 = 40%) which is equivalent to 9.8 cases per 10 000 glaucoma surgeries.
Conclusions
Sympathetic ophthalmia after glaucoma surgeries specifically, and IOS as a whole, is rare. The estimated incidence proportion of SO can be useful when consenting patients for surgery. Further research is needed to examine the effects of age, other ocular co-morbidities, as well as the type and number of previous intraocular surgeries, on the incidence of SO.