ESCRS - PO962 - Long-Term Treatment Outcomes Of Topical Tacrolimus Ointment Therapy For Stevens-Johnson Syndrome/Toxic Epidermal Necrosis

Long-Term Treatment Outcomes Of Topical Tacrolimus Ointment Therapy For Stevens-Johnson Syndrome/Toxic Epidermal Necrosis

Published 2024 - 42nd Congress of the ESCRS

Reference: PO962 | Type: Poster | DOI: 10.82333/tpat-jx94

Authors: Young Joon Choi* 1 , Seokoh Lee 1 , Hanju Kim 1 , Eunzee Lee 1

1Ophthalmology,Ajou University School of Medicine,Suwon,Korea, Republic Of

Purpose

It is known that performing amniotic membrane transplantation during the acute phase of Stevens-Johnson Syndrome (SJS)/Toxic Epidermal Necrolysis (TEN) reduces the incidence of ocular complications in the chronic phase. This study aims to investigate the long-term treatment outcomes in patients with acute SJS/TEN who did not undergo amniotic membrane transplantation but were treated with topical tacrolimus ointment.

Setting

Retrospective case series

Methods

This study retrospectively investigated patients diagnosed with SJS/TEN who were referred to the Department of Ophthalmology at Ajou University Hospital from March 2020 to September 2023 and underwent follow-up observation for at least 6 months. Patients were treated with topical tacrolimus ointment four times daily along with antibiotic eye drops, steroid eye drops, and artificial tears from the time of diagnosis, and their progress was monitored.

Results

A total of 9 eligible patients out of 13 were included in the study. The mean age was 45.6 years (range: 11-71), with 5 patients diagnosed with TEN and 4 with SJS. The mean acute systemic severity score was 6.1 (range: 4-8), and the mean acute ocular severity score was 1.67 (range: 1-2). Regarding chronic complications, Mucocutaneous junction involvement was observed in 5 patients, meibomian gland involvement in 5 patients, and Trichiasis in 1 patient. The mean chronic ocular complication score was 1.2 (range: 0-3). Other chronic ocular complications such as conjunctival adhesion, loss of palisade of Vogt, or corneal opacity were not observed.

Conclusions

The use of topical tacrolimus ointment in acute SJS/TEN patients with ocular complications effectively reduced the incidence and severity of chronic ocular complications even without amniotic membrane transplantation during the acute phase.