Clinical Features And Management Outcomes Of Isolated Corneal Intraepithelial Neoplasia

To report clinical features and treatment outcome of three cases with isolated corneal intraepithelial neoplasia (CIN)

Patients visiting the anterior segment clinic at King Khaled Eye Specialist Hospital.

This case series presents 3 patients with isolated CIN. Data collected included, presenting signs and symptoms including vision, anterior segment examination, medical and surgical outcomes and signs and symptoms at last post treatment visit.

Case 1 was a 45-year-old male who presented with an isolated grayish corneal lesion which was excised with alcohol assisted epitheliectomy, he also received 6 cycles of topical mitomycin C 0.02% and one injection of interferon alfa-2b with no recurrence during the 10-year follow-up period. Case 2 was 78-year-old male referred for a suspicious white corneal lesion which was completely excised, the patient also received 6 subconjunctival injections of interferon alpha-2b. However, the lesion recurred at 2.5-years post-treatment. Case 3 was a 63-year-old male patient who presented with an isolated corneal lesion that was excised, patient received four cycles of topical 5-fluorouracil with no recurrence at last follow-up visit at 6 months. 

Isolated corneal intraepithelial neoplasia (CIN) is a rare entity with few reported cases in the literature. In this case series, we report long and short-term management outcomes of combined surgical and medical therapy for isolated CIN.