Freeze Dried Versus Cryopreserved Amniotic Membrane For The Management Of Corneal Ulcers

Published 2024 - 42nd Congress of the ESCRS

Reference: PO932 | Type: Poster | DOI: 10.82333/ra17-9z62

Authors: Oumayma Elmansouri* ¹ , Houda Bezza ¹ , Housseine Aitlhaj ¹ , Mohamed Kriet ¹ , Fouad Elasri ¹

¹Ophthalmology department,Avicenna Military hospital,Marrakech,Morocco

Purpose

The aim of this research was to evaluate the effectiveness of freeze-dried amniotic membrane compared to cryopreserved amniotic membrane transplantation for managing corneal ulcers.

Setting

A retrospective study comparing the results of freeze dried and cryopreserved amniotic membrane transplantation surgeries performed at the military hospital of Marrakech From January 2020 to December 2023.

Methods

Thirty two corneal ulcers received Freeze dried amniotic membrane transplantation and 20 received cryopreserved amniotic membrane. Patients were followed up for at least 6 months. Patients were evaluated at baseline, 24 hours , 1 week , 1 month, and 3 months. The demographics, ulcer characteristics, results and complications were recorded and compared between the two groups.

Results

Baseline characteristics and clinical profiles of both groups were similar. There were no significant differences in the number of early detachments (P = 0.42). The membrane type did not affect corneal healing at 1 month (P = 0.35) or 3 months (P = 0.99), regardless of ulcer depth. However, deeper ulcers were less likely to heal at 3 months regardless of the Amniotic membrane type used (P = 0.01). There was no significant difference between the two groups regarding complication rates.

Conclusions

This study provides initial evidence supporting the effectiveness of freeze-dried amniotic membrane compared to cryopreserved amniotic membrane when utilized in transplantation for corneal ulcer treatment.