Repeatability Of Corneal Epithelial Thickness Measurements Using The Cirrus Oct® Epithelial Thickness Map In Eyes With Corneal Disease
Published 2024 - 42nd Congress of the ESCRS
Reference: PO915 | Type: Poster | DOI: 10.82333/ab4s-8596
Authors: Kyung Eun Han* 1 , Roo Min Jun 2 , Hyun Ji Jung 1 , Jee Eun Lee 1
1Ewha Womans University Mokdong Hospital,Seoul,Korea, Republic Of, 2Ewha Womans University Seoul Hospital,Seoul,Korea, Republic Of
Purpose
To evaluate the repeatability of corneal epithelial thickness (CET) measurements eyes with corneal disease using the epithelial thickness map of anterior segment optical coherence tomography (OCT).
Setting
Retrospectively, patients with 3 OCT scans using the epithelial thickness map mode of the Cirrus OCT® device at a single visit between October 2021 and January 2024 were reviewed. Two groups of subjects were included: (1) normal subjects with no history of ophthalmic surgery, corneal diseases, and topical antiglaucoma medication uses; and (2) subjects with corneal diseases including superficial punctate keratopathy, recurrent corneal erosion, pterygium, and others.
Methods
CET values of 57 eyes of 57 normal subjects and 110 eyes of 79 patients with corneal disease were included in this study. CET values of epithelial map were evaluated in 25 sectors: 1 sector within 0-2 mm in diameter, 8 sectors within 2-5 mm diameter, 8 sectors within 5-7 mm diameter, and 8 sectors within 7-9 mm diameter. CET values of epithelial map were evaluated in 25 sectors: 1 sector within 0-2 mm in diameter, 8 sectors within 2-5 mm diameter, 8 sectors within 5-7 mm diameter, and 8 sectors within 7-9 mm diameter. Repeatability of measurements was assessed using the intraclass correlation coefficient (ICC), coefficient of variation (CoV), and within-subject standard deviation (Sw).
Results
Among a total of 25 sectors, the normal eyes showed high repeatability (ICC > 0.75, CoV 2.17-5.29%, and Sw 0.76-1.65) in 23 sectors except for 2 sectors (7-9 mm superior and inferotemporal). In patients with corneal diseases also showed high repeatability (ICC >0.75, CoV 3.53~8.97%, Sw 1.29~3.37) in 22 sectors except for 3 sectors (7-9 mm superonasal, inferonasal, inferotemporal). In both groups, repeatability and measurement rate showed a decreasing trend as the diameter increased, and measurement rate at 7-9 mm zone were 93% (81~100%) in normal eyes and 82% (52~99%) in eyes with corneal disease.
Conclusions
Except for a several peripheral sectors, epithelial thickness map of the Cirrus OCT® provides repeatable CET measurements in both normal and eyes with corneal disease.