Clinical Outcomes And Complications After Cultivated Epithelial Sheet Transplantation In Eyes With Limbal Stem Cell Deficiency
Published 2024 - 42nd Congress of the ESCRS
Reference: PO910 | Type: Poster | DOI: 10.82333/mt09-bn83
Authors: Kaon Kataoka* 1 , Yurina Ogiwara 1 , Hiroshi Matsumae 2 , Yuta Tsukamoto 1 , Hirotsugu Kasamatsu 1 , Osama MA Ibrahim 1 , Yukari Yaguchi 1 , Daisuke Tomida 1 , Jun Shimazaki 1 , Takefumi Yamaguchi 1
1Department of ophthalmology,Tokyo Dental College Ichikawa General Hospital,Chiba,Japan, 2Department of ophthalmology,Okayama University Graduate School of Medicine,Okayama,Japan
Purpose
To evaluate the clinical outcomes and the incidence of complications after cultivated epithelial sheet transplantation for the treatment of limbal stem cell deficiency (LSCD).
Setting
This retrospective study included 12 eyes of 11 patients (4 females and 7 males, 57.8 ± 17.6 years old, range from 29 to 80, mean follow up period: 12.2 ± 7.7 months) with LSCD who underwent cultivated epithelial sheet transplantation (11 oral mucosal epithelial sheet [Ocural®], or 1 limbal epithelial sheet [Nepic®]) at Tokyo Dental College Ichikawa General Hospital from April 2022 to February 2024.
Methods
Cultivated epithelial sheet transplantation was performed for treating LSCD; 12 eyes using Ocural® in aniridia (4 eyes of 3 patients), idiopathic (3 eyes of 3 patients), ocular cicatricial pemphigoid (OCP; 2 eyes of 2 patients), and Stevens Johnson syndrome (SJS; 2 eyes of 2 patients) and using Nepic® in chemical burn (1 eye of 1 patient). Clinical outcomes (visual acuity and survival rate) as well as postoperative complications (epithelial defects, intraocular pressure (IOP) rise, and infection) were retrospectively evaluated.
Results
LogMAR visual acuity significantly improved from 1.95 ± 0.61 to 1.32 ± 0.58 at 1 month (n = 11, p = 0.0037), 1.40 ± 0.8 at 3 months (n = 9, p = 0.016), 1.24 ± 0.76 at 6 months (n = 9, p = 0.010), 1.24 ± 1.11 at 12 months (n = 7, p = 0.25). Graft survival rate was 100% at 1 month, 88% at 3 months, 77.8% at 6 months and 64.5% at 12 months. The causes of graft failure were recurrence in 2 eyes (both OCP) and infectious keratitis in 1 eye (SJS). Transient IOP raise (≧ 21 mmHg) developed in 5 eyes (42%) and IOP decreased to normal range in all eyes with tapering of steroid eye drops. Epithelial defects occurred in 4 eyes (33%) in which persistent defect refractory to conventional treatment resulted in infectious keratitis in 1 eye (8%).
Conclusions
Overall clinical outcome of cultivated epithelial sheet transplantation for treating LSCD was favorable and an effective treatment.