Analysis Of Central Corneal Thickness In Systemic Lupus Erythematosus And Its Potential Implications.
Published 2024 - 42nd Congress of the ESCRS
Reference: PO907 | Type: Poster | DOI: 10.82333/yke1-3g97
Authors: Juan David Saldaña Garrido* 1 , Mario Cantó Cerdán 2 , Vicente Francisco Gil Guillén 3 , María Luisa Alfaro Beltrá 4 , Francisca Sivera Mascaró 5
1Ophthalmology,Elda General University Hospital,Elda, Alicante,Spain;Clinical Medicine,School of Medicine. Miguel Hernández de Elche University,Alicante,Spain, 2Optometry,Vissum Miranza,Alicante,Spain, 3Investigations,Elda General University Hospital,Elda, Alicante,Spain;Clinical Medicine,School of Medicine. Miguel Hernández de Elche University,Alicante,Spain, 4Ophthalmology,Elda General University Hospital,Elda, Alicante,Spain, 5Reumathology,Elda General University Hospital,Elda, Alicante,Spain;Clinical Medicine,School of Medicine. Miguel Hernández de Elche University,Alicante,Spain
Purpose
To investigate the relationship between central corneal thickness (CCT) and Systemic Lupus Erythematosus (SLE) while comparing the mean CCT values between SLE patients and healthy controls.
Setting
Clinical Medicine Department from Miguel Hernández de Elche University. Ophthalmology Department from Elda General University Hospital. Alicante, Spain.
Methods
A cross-sectional observational study was conducted, enrolling 71 participants, 36 with SLE (group 1) and 35 healthy controls (group 2), recruited from ophthalmology consultations. Controls were matched by sex and age, with exclusion criteria for other corneal thinning risk factors. Prior to the main study, a pilot study was performed to estimate the sample size. A concordance analysis was performed using the Kappa index. CCT measurements were obtained using the Zeiss HD Cirrus 5000 optical coherence tomography (OCT) of a randomly selected eye. Correlation analysis was conducted using Spearman's Rho coefficient while a Loess regression was employed to visualize both linear and non-linear trends in the data.
Results
Kappa index analysis revealed a perfect correlation between eyes and only one eye per patient was randomly selected. SLE group presented significantly thicker CCT compared to controls (536.44±39.91 µm vs 517.57±29.62 µm, p=0.014). No significant differences in intraocular pressure (IOP) were observed (SLE 14.31 ± 3.12 mmHg vs controls 14.54± 2.36 mmHg, p=0.898). A significantly positive correlation was identified between the duration of hydroxychloroquine use and CCT (R: 0.357; p=0.041). Multivariate logistic regression showed an odds ratio (OR) of 1.016 (95% CI: 1.001-1.031), indicating association between CCT and SLE presence (p=0.033). Adjustment for age and sex did not alter OR significance, suggesting no modification of CCT's effect.
Conclusions
We stablish an association between CCT and the presence of SLE, wherein SLE patients exhibit significantly thicker CCT compared to controls. This observation may be attributed to hydroxychloroquine usage, as CCT demonstrates a trend of increase with prolonged use, peaking around 100 months before stabilization. This should be considered in the assessment of IOP and the risk of glaucoma in patients with SLE.