A Five-Year Retrospective Analysis Of Amniotic Membrane Transplantation In Ophthalmology: Insights From A Single Center
Published 2024 - 42nd Congress of the ESCRS
Reference: PO903 | Type: Free paper | DOI: 10.82333/ep28-vg32
Authors: João Castro Cabanas* 1 , Catarina Ferreira 1 , Pedro Moreira Martins 1 , Ricardo Machado Soares 1 , Filipe Sousa Neves 1 , Joaquim Sequeira 1 , Carlos Arede 1
1Ophthalmology,Unidade Local de Saúde Gaia e Espinho,Vila Nova de Gaia,Portugal
Purpose
Amniotic membrane transplantation (AMT) has emerged as a versatile therapeutic tool in ophthalmology and other medical fields, due to its unique properties, including anti-inflammatory and regenerative capabilities. Its application spans diverse clinical indications. In our study, we sought to comprehensively assess the indications for amniotic graft transplantation in our ophthalmology department and to evaluate both the overall success rate of amniotic graft transplantation and specific success rates in four distinct patient groups.
Setting
Department of Ophthalmology, Unidade Local de Saúde Gaia e Espinho
Methods
Retrospective case series including patients submitted to amniotic graft surgery performed between 2018 and 2023 in the department of Ophthalmology at Unidade Local de Saúde Gaia e Espinho. Medical records were reviewed for the patient’s demographics and clinical data. The sample was divided into groups according to the underlying pathology and indication for amniotic graft transplantation: 1) corneal microperforation, 2) corneal ulcer, 3) conjunctival disease, and 4) miscellaneous. Surgical success was defined as effectiveness of AMT in achieving the desired outcome according to the underlying ophthalmic condition and was evaluated at 1 month follow-up.
Results
A total of 35 eyes from 34 patients were included, comprising a total of 42 amniotic graft surgeries between 2018 and 2023 In the first group, including eyes with corneal microperforations (n=10), AMT was successful in containing the corneal defect in all cases. The second group encompassed eyes with corneal ulcers (n=13), with an overall success rate of 76.9% due to 3 unsuccessful cases. The third group accounted for 12 surgeries in eyes with different conjunctival conditions with a success rate of 83.3%. Miscellaneous indications were included in group 4 and demonstrated a success rate of 85.7%. The overall success rate for all surgeries was 85.7%. None of the eyes presented AMT related adverse effects or complications.
Conclusions
In our department sample, AMT demonstrated to be an effective and safe treatment option across a diverse spectrum of ophthalmic indications.